Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study
Articolo
Data di Pubblicazione:
2023
Citazione:
Probiotics and Prebiotics Orally Assumed as Disease Modifiers for Stable Mild Atopic Dermatitis: An Italian Real-Life, Multicenter, Retrospective, Observational Study / D. Colombo, C. Rigoni, A. Cantù, A. Carnevali, R. Filippetti, T. Franco, A. Grassi, C. Loi, A. Mazzotta, I. Patroi, B. Raone, M. Andrea Tomassini, A. Amoruso, M. Pane, G. Damiani. - In: MEDICINA. - ISSN 1648-9144. - 59:12(2023), pp. 2080.1-2080.9. [10.3390/medicina59122080]
Abstract:
The role of the skin–gut axis in atopic dermatitis (AD) remains a subject of debate, limiting
non-pharmacological interventions such as probiotics and prebiotics. To improve understanding
of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter,
retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium
animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05)
orally to patients with mild atopic dermatitis without a placebo control group, following up for
12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area
and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled
patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema,
edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001)
after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential
link between the skin–gut microbiome and support the rationale for using specific probiotics and
prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.
non-pharmacological interventions such as probiotics and prebiotics. To improve understanding
of their potential as a monotherapy for stable mild cases, we conducted a real-life, multicenter,
retrospective observational study in Italy. We administered three selected bacteria (Bifidobacterium
animalis subsp. lactis BS01, Lactiplantibacillus plantarum LP14, and Lacticaseibacillus rhamnosus LR05)
orally to patients with mild atopic dermatitis without a placebo control group, following up for
12 weeks. Clinical assessments using the Scoring Atopic Dermatitis (SCORAD), Eczema Area
and Severity Index (EASI), and Three-Item Severity (TIS) score were conducted on 144 enrolled
patients (average age: 25.1 ± 17.6 years). Notably, both pruritus and AD-related lesions (erythema,
edema/papules, excoriation) exhibited significant clinical and statistical improvement (p < 0.001)
after 12 weeks of exclusive probiotic and prebiotic use. These preliminary results suggest a potential
link between the skin–gut microbiome and support the rationale for using specific probiotics and
prebiotics in mild AD, even for maintenance, to reduce flares and dysbiosis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
atopic dermatitis; probiotics; prebiotics; Bifidobacterium animalis subsp. lactis BS01; Lactiplantibacillus plantarum LP14; Lacticaseibacillus rhamnosus LR05; mild atopic dermatitis; prevention
Elenco autori:
D. Colombo, C. Rigoni, A. Cantù, A. Carnevali, R. Filippetti, T. Franco, A. Grassi, C. Loi, A. Mazzotta, I. Patroi, B. Raone, M. Andrea Tomassini, A. Amoruso, M. Pane, G. Damiani
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