Histone Deacetylase Complex 1 and histone 1 epigenetically moderate stress responsiveness of Arabidopsis thaliana seedlings
Articolo
Data di Pubblicazione:
2023
Citazione:
Histone Deacetylase Complex 1 and histone 1 epigenetically moderate stress responsiveness of Arabidopsis thaliana seedlings / G. Perrella, C. Fasano, N.A. Donald, L. Daddiego, W. Fang, D. Martignago, C. Carr, L. Conti, P. Herzyk, A. Amtmann. - In: NEW PHYTOLOGIST. - ISSN 0028-646X. - (2023), pp. 1-14. [Epub ahead of print] [10.1111/nph.19165]
Abstract:
Early responses of plants to environmental stress factors prevent damage but can delay growth and development in fluctuating conditions. Optimising these trade-offs requires tunability of plant responsiveness to environmental signals.
We have previously reported that Histone Deacetylase Complex 1 (HDC1), which interacts with multiple proteins in histone deacetylation complexes, regulates the stress responsiveness of Arabidopsis seedlings, but the underlying mechanism remained elusive.
Here, we show that HDC1 attenuates transcriptome re-programming in salt-treated seedlings, and we identify two genes (LEA and MAF5) that inhibit seedling establishment under salt stress downstream of HDC1. HDC1 attenuates their transcriptional induction by salt via a dual mechanism involving H3K9/14 deacetylation and H3K27 trimethylation. The latter, but not the former, was also abolished in a triple knockout mutant of the linker histone H1, which partially mimics the hypersensitivity of the hdc1-1 mutant to salt stress. Although stress-induced H3K27me3 accumulation required both H1 and HDC1, it was not fully recovered by complementing hdc1-1 with a truncated, H1-binding competent HDC1 suggesting other players or independent inputs.
The combined findings reveal a dual brake function of HDC1 via regulating both active and repressive epigenetic marks on stress-inducible genes. This natural ‘anti-panic’ device offers a molecular leaver to tune stress responsiveness in plants.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Arabidopsis; germination; histone modifications; salt stress; transcriptional regulation; transcriptomics
Elenco autori:
G. Perrella, C. Fasano, N.A. Donald, L. Daddiego, W. Fang, D. Martignago, C. Carr, L. Conti, P. Herzyk, A. Amtmann
Link alla scheda completa: