Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring
Articolo
Data di Pubblicazione:
2023
Citazione:
Incidence of ventricular arrhythmias related to COVID infection and vaccination in patients with Brugada syndrome: Insights from a large Italian multicenter registry based on continuous rhythm monitoring / M. Casella, S. Conti, P. Compagnucci, V. Ribatti, M.L. Narducci, L. Marcon, F. Massara, Y. Valeri, L. De Francesco, A.M. Martino, C. Ghiglieno, M. Schiavone, C. Balla, G. Dell'Era, G. Pelargonio, G.B. Forleo, S. Iacopino, G. Sgarito, L. Calò, C. Tondo, A.D. Russo, G. Patti. - In: JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY. - ISSN 1045-3873. - (2023), pp. 1-9. [10.1111/jce.15929]
Abstract:
Introduction: Brugada syndrome (BrS) has a dynamic ECG pattern that might be revealed by certain conditions such as fever. We evaluated the incidence and management of ventricular arrhythmias (VAs) related to COVID-19 infection and vaccination among BrS patients carriers of an implantable loop recorder (ILR) or implantable cardioverter-defibrillator (ICD) and followed by remote monitoring. Methods: This was a multicenter retrospective study. Patients were carriers of devices with remote monitoring follow-up. We recorded VAs 6 months before COVID-19 infection or vaccination, during infection, at each vaccination, and up to 6-month post-COVID-19 or 1 month after the last vaccination. In ICD carriers, we documented any device intervention. Results: We included 326 patients, 202 with an ICD and 124 with an ILR. One hundred and nine patients (33.4%) had COVID-19, 55% of whom developed fever. Hospitalization rate due to COVID-19 infection was 2.76%. After infection, we recorded only two ventricular tachycardias (VTs). After the first, second, and third vaccines, the incidence of non-sustained ventricular tachycardia (NSVT) was 1.5%, 2%, and 1%, respectively. The incidence of VT was 1% after the second dose. Six-month post-COVID-19 healing or 1 month after the last vaccine, we documented NSVT in 3.4%, VT in 0.5%, and ventricular fibrillation in 0.5% of patients. Overall, one patient received anti-tachycardia pacing and one a shock. ILR carriers had no VAs. No differences were found in VT before and after infection and before and after each vaccination. Conclusions: From this large multicenter study conducted in BrS patients, followed by remote monitoring, the overall incidence of sustained VAs after COVID-19 infection and vaccination is relatively low.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Brugada syndrome; COVID-19; fever; implantable cardioverter defibrillator; loop recorder; remote monitoring; vaccine
Elenco autori:
M. Casella, S. Conti, P. Compagnucci, V. Ribatti, M.L. Narducci, L. Marcon, F. Massara, Y. Valeri, L. De Francesco, A.M. Martino, C. Ghiglieno, M. Schiavone, C. Balla, G. Dell'Era, G. Pelargonio, G.B. Forleo, S. Iacopino, G. Sgarito, L. Calò, C. Tondo, A.D. Russo, G. Patti
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