Low-Molecular-Weight Phosphatase B (LMW-MPtpB) inhibition as a strategy to identify new drug candidates against tuberculosis
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Data di Pubblicazione:
2021
Citazione:
Low-Molecular-Weight Phosphatase B (LMW-MPtpB) inhibition as a strategy to identify new drug candidates against tuberculosis / M. Mori, G. Cazzaniga, L.R. Chiarelli, G. Stelitano, S. Ciceri, T. Tuccinardi, G. Poli, F. Meneghetti, S. Villa. ((Intervento presentato al 27. convegno Congresso Nazionale della Società Chimica Italiana tenutosi a Online nel 2021.
Abstract:
The last WHO Global TB Report estimated that 10 million people worldwide fell ill with tuberculosis
(TB) in 2019. The resistance to anti-TB drugs is a global health problem that interferes with the
progress of TB eradication. Hence, novel and more effective anti-TB drugs acting on unexplored
targets are needed to contrast the resistance phenomenon and the progressive loss of antibiotic
efficacy, and to improve the current therapies. Mycobacterium tuberculosis (Mtb) secretes two Low-
Molecular-Weight Phosphatases (LMW-PTPs), MPtpA and MPtpB, inside the cytoplasm of host
macrophages. These enzymes are indispensable for the intracellular survival of Mtb because they
interfere with the host immune response, thus allowing bacteria to evade the immune system. For this
reason, MPtpA and MPtpB were validated as promising targets for the development of innovative
antitubercular agents.
Recent computational studies defined a new pharmacophore model, which was applied to screen two
commercial databases, Vitas-M and Enamine. These virtual screening experiments led to the selection
of 8 molecules for MPtpB inhibition (see Figure 1).
The biological data will be discussed, along with preliminary investigations on the most promising
candidates.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
M. Mori, G. Cazzaniga, L.R. Chiarelli, G. Stelitano, S. Ciceri, T. Tuccinardi, G. Poli, F. Meneghetti, S. Villa
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