Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals
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Data di Pubblicazione:
2023
Citazione:
Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals / F. Gado, G. Ferrario, L. DELLA VEDOVA, B. Zoanni, A.A. Altomare, M. Carini, G. Aldini, A. D'Amato, G. Baron. - In: MOLECULES. - ISSN 1420-3049. - 28:3(2023 Jan 31), pp. 1356.1-1356.14. [10.3390/molecules28031356]
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Targeting Nrf2 and NF-κB Signaling Pathways in Cancer Prevention: The Role of Apple Phytochemicals
by Francesca Gado
[ORCID] , Giulio Ferrario
[ORCID] , Larissa Della Vedova
[ORCID] , Beatrice Zoanni
, Alessandra Altomare
[ORCID] , Marina Carini
, Giancarlo Aldini
[ORCID] , Alfonsina D’Amato
* [ORCID] and Giovanna Baron
[ORCID]
Department of Pharmaceutical Sciences (DISFARM), State University of Milan, Via Mangiagalli 25, 20133 Milan, Italy
*
Author to whom correspondence should be addressed.
Molecules 2023, 28(3), 1356; https://doi.org/10.3390/molecules28031356
Received: 31 December 2022 / Revised: 27 January 2023 / Accepted: 28 January 2023 / Published: 31 January 2023
(This article belongs to the Special Issue Recent Advances in Development of Small Molecules to Fight Cancer)
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Abstract
Plant secondary metabolites, known as phytochemicals, have recently gained much attention in light of the “circular economy”, to reutilize waste products deriving from agriculture and food industry. Phytochemicals are known for their onco-preventive and chemoprotective effects, among several other beneficial properties. Apple phytochemicals have been extensively studied for their effectiveness in a wide range of diseases, cancer included. This review aims to provide a thorough overview of the main studies reported in the literature concerning apple phytochemicals, mostly polyphenols, in cancer prevention. Although there are many different mechanisms targeted by phytochemicals, the Nrf2 and NF-κB signaling pathways are the ones this review will be focused on, highlighting also the existing crosstalk between these two systems.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
phytochemicals; apple polyphenols; Nrf2 signaling pathway; NF-κB signaling pathway; anti-cancer activity; Nrf2/NF-κB crosstalk; secondary metabolites; circular economy;
Elenco autori:
F. Gado, G. Ferrario, L. DELLA VEDOVA, B. Zoanni, A.A. Altomare, M. Carini, G. Aldini, A. D'Amato, G. Baron
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