Synthesis of indoles by intermolecular cyclization of unfunctionalized nitroarenes and alkynes : one step synthesis of the skeleton of fluvastatin
Articolo
Data di Pubblicazione:
2009
Citazione:
Synthesis of indoles by intermolecular cyclization of unfunctionalized nitroarenes and alkynes : one step synthesis of the skeleton of fluvastatin / F. Ragaini, F. Ventriglia, M. Hagar, S. Fantauzzi, S. Cenini. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - :13(2009), pp. 2185-2189. [10.1002/ejoc.200801274]
Abstract:
The addition of Ru3(CO)12, dimethylcarbonate, or both to the reaction mixture improves the selectivity of the palladium-phenanthroline catalyzed reaction of nitroarenes, arylalkynes and CO to give 3-arylindoles. When 4-fluorophenylacetylene and nitrobenzene are used as substrates, the indole skeleton of Fluvastatin and other pharmaceutically active compounds is obtained in one step.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alkynes /; Arenes /; Carbonylation; Nitrogen heterocycles /; Palladium /
Elenco autori:
F. Ragaini, F. Ventriglia, M. Hagar, S. Fantauzzi, S. Cenini
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