Correlation between Perturbation of Redox Homeostasis and Antibiofilm Capacity of Phytochemicals at Non-Lethal Concentrations
Articolo
Data di Pubblicazione:
2022
Citazione:
Correlation between Perturbation of Redox Homeostasis and Antibiofilm Capacity of Phytochemicals at Non-Lethal Concentrations / M.S. Christodoulou, F. Villa, A. Pinto, F. Cappitelli. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 11:12(2022), pp. 2451.1-2451.26. [10.3390/antiox11122451]
Abstract:
Biofilms are the multicellular lifestyle of microorganisms and are present on potentially
every type of biotic or abiotic surface. Detrimental biofilms are generally targeted with antimicrobial
compounds. Phytochemicals at sub-lethal concentrations seem to be an exciting alternative strategy
to control biofilms, as they are less likely to impose selective pressure leading to resistance. This
overview gathers the literature on individual phytocompounds rather than on extracts of which
the use is difficult to reproduce. To the best of our knowledge, this is the first review to target only
individual phytochemicals below inhibitory concentrations against biofilm formation. We explored
whether there is an overall mechanism that can explain the effects of individual phytochemicals at
sub-lethal concentrations. Interestingly, in all experiments reported here in which oxidative stress
was investigated, a modest increase in intracellular reactive oxygen species was reported in treated
cells compared to untreated specimens. At sub-lethal concentrations, polyphenolic substances likely
act as pro-oxidants by disturbing the healthy redox cycle and causing an accumulation of reactive
oxygen species.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
iocide-free antibiofilm substances; phenolic phytochemicals; sub-lethal concentrations; reactive oxygen species; antioxidants and pro-oxidants
Elenco autori:
M.S. Christodoulou, F. Villa, A. Pinto, F. Cappitelli
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