Data di Pubblicazione:
1995
Citazione:
A Novel Action for Adenosine: Apoptosis of Astroglial Cells in Rat-Brain Primary Cultures / M.P. Abbracchio, S. Ceruti, D. Barbieri, C. Franceschi, W. Malorni, L. Biondo, G. Burnstock, F. Cattabeni. - In: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. - ISSN 0006-291X. - 213:3(1995 Aug 24), pp. 908-915. [10.1006/bbrc.1995.2215]
Abstract:
2-chloro-adenosine induced apoptosis of astroglial cells in rat brain cultures, as shown by flow cytometry and morphological analysis. The adenosine analogue was far more potent than several previously characterized sugars (including 2-deoxy-D-ribose and D-ribose, the sugar moiety of 2-chloro-adenosine), which trigger apoptosis in a variety of cell-lines [8-10], suggesting that the effects of 2-chloro-adenosine are only partially dictated by its sugar moiety. Nevertheless, 2-chloro-adenosine and 2-deoxy-D-ribose attenuated each other's cell death when used in combination, suggesting the involvement of common intracellular mechanisms. It is suggested that 2-chloro-adenosine may induce apoptosis via a yet-to-be identified adenosine receptor, which may have intriguing implications for both nervous system development and brain response to trauma and ischemia. (C) 1995 Academic Press, Inc.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
2-Chloroadenosine; Animals; Apoptosis; Astrocytes; Cells, Cultured; Corpus Striatum; Deoxyribose; Enzyme Activation; Poly(ADP-ribose) Polymerases; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship;
Elenco autori:
M.P. Abbracchio, S. Ceruti, D. Barbieri, C. Franceschi, W. Malorni, L. Biondo, G. Burnstock, F. Cattabeni
Link alla scheda completa: