Data di Pubblicazione:
2022
Citazione:
Methyl 5-(2-Fluoro-4-nitrophenyl)furan-2-carboxylate / M. Mori, A. Tresoldi, G. Cazzaniga, F. Meneghetti, S. Villa. - In: MOLBANK. - ISSN 1422-8599. - 2022:(2022 Nov 12), pp. M1492.1-M1492.10. [10.3390/M1492]
Abstract:
5-Phenyl-furan-2-carboxylic acids have emerged as a new, promising class of antimycobacterial agents that have the ability to interfere with iron homeostasis. Considering the lack of structural data on these compounds, we analyzed the crystal of a fluorinated ester derivative of 5-(4-nitrophenyl)furan-2-carboxylic acid, one of the most potent candidates in the series. Here, we describe the preparation of methyl 5-(2-fluoro-4-nitrophenyl)furan-2-carboxylate (1) and its analysis by 1H-NMR, 13C-NMR, HRMS, and SC-XRD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
furan; SC-XRD; Mycobacterium tuberculosis; antitubercular agent; iron acquisition; MbtI;
Elenco autori:
M. Mori, A. Tresoldi, G. Cazzaniga, F. Meneghetti, S. Villa
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