Data di Pubblicazione:
2008
Citazione:
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage / L. Sironi, N. Mitro, M. Cimino, P. Gelosa, U. Guerrini, E. Tremoli, E. Saez. - In: FEBS LETTERS. - ISSN 0014-5793. - 582:23-24(2008), pp. 3396-3400. [10.1016/j.febslet.2008.08.035]
Abstract:
Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, including neuroinflammation. However, the ability of LXR agonists to suppress stroke-associated inflammation has not been evaluated. Here, we have used time-lapse magnetic resonance imaging (MRI) to show that a single dose of an LXR ligand administered post-injury dramatically reduces brain damage in a model of acute brain ischemia. Neuroprotection was associated with suppression of neuroinflammation
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acute cerebral ischemia ; Experimental therapy ; Neuroprotection ; Nuclear receptor ; Transcriptional activator
Elenco autori:
L. Sironi, N. Mitro, M. Cimino, P. Gelosa, U. Guerrini, E. Tremoli, E. Saez
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