Data di Pubblicazione:
2022
Citazione:
Antiparasitic Drugs against SARS-CoV-2: A Comprehensive Literature Survey / E. Calvo Alvarez, M. Dolci, F. Perego, L. Signorini, S. Parapini, S. D'Alessandro, L. Denti, N. Basilico, D. Taramelli, P. Ferrante, S. Delbue. - In: MICROORGANISMS. - ISSN 2076-2607. - 10:7(2022), pp. 1284.1-1284.34. [10.3390/microorganisms10071284]
Abstract:
More than two years have passed since the viral outbreak that led to the novel infectious
respiratory disease COVID-19, caused by the SARS-CoV-2 coronavirus. Since then, the urgency for
effective treatments resulted in unprecedented efforts to develop new vaccines and to accelerate the
drug discovery pipeline, mainly through the repurposing of well-known compounds with broad
antiviral effects. In particular, antiparasitic drugs historically used against human infections due
to protozoa or helminth parasites have entered the main stage as a miracle cure in the fight against
SARS-CoV-2. Despite having demonstrated promising anti-SARS-CoV-2 activities in vitro, conflicting
results have made their translation into clinical practice more difficult than expected. Since many
studies involving antiparasitic drugs are currently under investigation, the window of opportunity
might be not closed yet. Here, we will review the (controversial) journey of these old antiparasitic
drugs to combat the human infection caused by the novel coronavirus SARS-CoV-2.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
anthelmintics; antimalarials; antiparasitics; COVID-19; drug repurposing; SARS-CoV-2
Elenco autori:
E. Calvo Alvarez, M. Dolci, F. Perego, L. Signorini, S. Parapini, S. D'Alessandro, L. Denti, N. Basilico, D. Taramelli, P. Ferrante, S. Delbue
Link alla scheda completa:
Link al Full Text: