Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia

Articolo

Data di Pubblicazione:

2022

Citazione:

Lack of ApoA-I in ApoEKO Mice Causes Skin Xanthomas, Worsening of Inflammation, and Increased Coronary Atherosclerosis in the Absence of Hyperlipidemia / M. Busnelli, S. Manzini, A. Colombo, E. Franchi, F. Bonacina, M. Chiara, F. Arnaboldi, E. Donetti, F. Ambrogi, R. Oleari, A. Lettieri, D. Horner, E. Scanziani, G.D. Norata, G. Chiesa. - In: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. - ISSN 1079-5642. - (2022). [Epub ahead of print] [10.1161/ATVBAHA.122.317790]

Abstract:

HDL (High-density lipoprotein) and its major protein component, apoA-I (apolipoprotein A-I), play a unique role in cholesterol homeostasis and immunity. ApoA-I deficiency in hyperlipidemic, atheroprone mice was shown to drive cholesterol accumulation and inflammatory cell activation/proliferation. The present study was aimed at investigating the impact of apoA-I deficiency on lipid deposition and local/systemic inflammation in normolipidemic conditions.

Tipologia IRIS:

01 - Articolo su periodico

Keywords:

atherosclerosis; hyperlipidemias; inflammation; lymph nodes; xanthoma

Elenco autori: