Sub-Minimum Inhibitory Concentrations of Ceftibuten Reduce Adherence of Escherichia coli to Human Cells and Induces Formation of Long Filaments
Articolo
Data di Pubblicazione:
1993
Citazione:
Sub-Minimum Inhibitory Concentrations of Ceftibuten Reduce Adherence of Escherichia coli to Human Cells and Induces Formation of Long Filaments / P.C. Braga, G. Piatti. - In: MICROBIOLOGY AND IMMUNOLOGY. - ISSN 0385-5600. - 37:3(1993), pp. 175-179. [10.1111/j.1348-0421.1993.tb03197.x]
Abstract:
The minimal inhibitory concentrations (MICs) of an antibiotic are present for only a certain period of time, after which they become sub-inhibitory concentrations (sub-MICs). These sub-MICs are still active because they can interfere with the mechanism of bacterial adhesion, which is the first step in the sequence of events leading to infection. The purpose of the present study was to investigate the effects of sub-MICs of ceftibuten, a new third-generation ce-phalosporin, on the adhesion of Escherichia coli (E. coli) to human buccal cells. The degree of inhibition was maximal at 1/2 MIC and then gradually returned toward to the control values at 1/128 the MIC. The differences were statistically significant from 1/2 to 1/32 MIC. Since the MIC was 0.5 fig/ml, concentrations from 0.25 to 0.015 Mg/ml significantly reduce bacterial adhesion. Ceftibuten also caused marked elongation of E. coli. These findings could help to explain the efficacy showed by ceftibuten in the treatment of respiratory and urinary tract infections when administered once daily.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Ceftibuten; Escherichia coli; Inhibition of adhesion; Once-a-day therapy; Bacterial Adhesion; Ceftibuten; Cells, Cultured; Cephalosporins; Escherichia coli; Humans; Microbial Sensitivity Tests; Mouth Mucosa
Elenco autori:
P.C. Braga, G. Piatti
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