Intrauterine growth restriction is associated with alterations in placental lipoprotein receptors and maternal lipoprotein composition
Articolo
Data di Pubblicazione:
2007
Citazione:
Intrauterine growth restriction is associated with alterations in placental
lipoprotein receptors and maternal lipoprotein composition / C. Wadsack, S. Tabano, A. Maier, U. Hiden, G. Alvino, V. Cozzi, M. Huttinger, W. Schneider, U. Lang, I. Cetin, G. Desoye. - In: AMERICAN JOURNAL OF PHYSIOLOGY: ENDOCRINOLOGY AND METABOLISM. - ISSN 0193-1849. - 292:2(2007), pp. E476-E484.
Abstract:
Among other factors, fetal growth requires maternal supply of cholesterol.
Cellular cholesterol uptake is mainly mediated by the LDL receptor
(LDL-R) and the scavenger receptor family. We hypothesized that
expression levels of key receptors of these families were regulated
differently in placentas from IUGR pregnancies with varying degrees
of severity. Third-trimester placentas from IUGR pregnancies with
(IUGR-S) and without (IUGR-M) fetal hemodynamic changes and
from control (AGA) pregnancies were studied. LDL-R, LDL-Rrelated
protein (LRP-1), and scavenger receptor class B type I (SR-BI)
mRNA and protein levels were measured. Cholesterol concentration
and composition of lipoproteins were analyzed enzymatically and by
lipid electrophoresis, respectively, in maternal and umbilical cord
blood. LDL-R mRNA levels in IUGR-M were similar to AGA but
lower (P ! 0.05) in IUGR-S. In contrast, LDL-R protein was twofold
(IUGR-M) and 1.8-fold (IUGR-S) higher (P ! 0.05) than in the AGA
group. LRP-1 mRNA and protein levels were not altered in the IUGR
cases. SR-BI mRNA was unchanged in IUGR, but protein levels were
lower (P ! 0.05) in IUGR-S than in the other groups. Maternal
plasma concentrations of LDL cholesterol were higher (P ! 0.05) in
the AGA group (188.5 " 23.6 mg/dl) than in the IUGR-S group
(154.2 " 26.1). Electrophoretic mobility of the LDL fraction in
maternal plasma demonstrated significant changes in migration toward
higher values (AGA 0.95 " 0.06, IUGR-M 1.12 " 0.11, P !
0.001; IUGR-S 1.28 " 0.20, P # 0.002). We conclude that LDL-R
and SR-BI levels are altered in IUGR pregnancies. These differences
were associated with changes in LDL, but not HDL, mobility and cholesterol concentration in maternal circulation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Fetal growth; Lipids; Placenta; Pregnancy
Elenco autori:
C. Wadsack, S. Tabano, A. Maier, U. Hiden, G. Alvino, V. Cozzi, M. Huttinger, W. Schneider, U. Lang, I. Cetin, G. Desoye
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