Data di Pubblicazione:
2022
Citazione:
Double-Layer Fatty Acid Nanoparticles as a Multiplatform for Diagnostics and Therapy / M. Salvador, J. Luis Marqués-Fernández, J. Carlos Martínez-García, D. Fiorani, P. Arosio, M. Avolio, F. Brero, F. Balanean, A. Guerrini, C. Sangregorio, V. Socoliuc, L. Vekas, D. Peddis, M. Rivas. - In: NANOMATERIALS. - ISSN 2079-4991. - 12:2(2022 Jan 02), pp. 205.1-205.18. [10.3390/nano12020205]
Abstract:
Today, public health is one of the most important challenges in society. Cancer is the leading
cause of death, so early diagnosis and localized treatments that minimize side effects are a priority.
Magnetic nanoparticles have shown great potential as magnetic resonance imaging contrast agents,
detection tags for in vitro biosensing, and mediators of heating in magnetic hyperthermia. One of
the critical characteristics of nanoparticles to adjust to the biomedical needs of each application is
their polymeric coating. Fatty acid coatings are known to contribute to colloidal stability and good
surface crystalline quality. While monolayer coatings make the particles hydrophobic, a fatty acid
double-layer renders them hydrophilic, and therefore suitable for use in body fluids. In addition,
they provide the particles with functional chemical groups that allow their bioconjugation. This
work analyzes three types of self-assembled bilayer fatty acid coatings of superparamagnetic iron
oxide nanoparticles: oleic, lauric, and myristic acids. We characterize the particles magnetically and
structurally and study their potential for resonance imaging, magnetic hyperthermia, and labeling
for biosensing in lateral flow immunoassays. We found that the myristic acid sample reported a
large r2 relaxivity, superior to existing iron-based commercial agents. For magnetic hyperthermia,
a significant specific absorption rate value was obtained for the oleic sample. Finally, the lauric acid
sample showed promising results for nanolabeling.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
magnetic nanoparticles; magnetic hyperthermia; magnetic relaxation; magnetic resonance imaging; biosensor; lateral flow immunoassays; inductive sensing;
Elenco autori:
M. Salvador, J. Luis Marqués-Fernández, J. Carlos Martínez-García, D. Fiorani, P. Arosio, M. Avolio, F. Brero, F. Balanean, A. Guerrini, C. Sangregorio, V. Socoliuc, L. Vekas, D. Peddis, M. Rivas
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