CASOLA STEFANO

Nome: Stefano Casola

Affiliazione:
1. Universita’ degli Studi di Milano, Dipartimento di Biotecnologie Mediche e Medicina Traslazionale (BIOMETRA).
2. IFOM - Istituto AIRC di Oncologia Molecolare, Milano, Italia

Contatti: stefano.casola@unimi.it; stefano.casola@ifom.eu;

ORCID: https://orcid.org/0000-0001-5580-0986

Formazione
• 1993 Laurea in Medicina e Chirurgia, Università degli Studi di Napoli Federico II, Italia
• 1999 Dottorato di Ricerca (Ph.D.), Università degli Studi di Napoli Federico II, Italia

Abilitazione professionale
• 1994 Abilitazione all’esercizio della professione medica (Italia)

Formazione post-dottorato
• 1997–2001 Istituto di Genetica, Università di Colonia, Germania (Laboratorio del Dr. Klaus Rajewsky)

Incarichi accademici e di ricerca
• 2001–2006 Instructor, Dipartimento di Patologia, Harvard Medical School, Boston, USA
• 2001–2006 Junior Investigator, CBR Institute for Biomedical Research, Harvard Medical School, Boston, USA
• 2006–2013 Junior Group Leader, IFOM – Istituto AIRC di Oncologia Molecolare, Milano
• 2013–oggi Senior Group Leader, IFOM – Istituto AIRC di Oncologia Molecolare, Milano
• 2024–oggi Professore Associato di Patologia Generale, Università degli Studi di Milano
• 2006–oggi Membro del Collegio Docenti, Scuola di Dottorato SEMM di Systems Medicine, Università di Milano
• 2023–oggi Membro del Collegio Docenti, Scuola di Dottorato Translational Medicine, Scuola Superiore Sant’Anna, Pisa

Premi e riconoscimenti
• 1996 Premio SIBBM per la migliore pubblicazione scientifica da studente di dottorato
• 1997 Borsa post-doc, Alexander von Humboldt Foundation
• 1997 Borsa post-doc, European Molecular Biology Organization (EMBO)
• 1997 Borsa post-doc, Human Frontiers in Science Program (HFSP)
• 1997 Borsa post-doc, Cancer Research Institute
• 2006 Career Development Award, Armenise-Harvard Foundation
• 2006 New AIRC Start-up unit award, Associazione Italiana Ricerca sul Cancro (AIRC)

Appartenenze a società scientifiche
• Dal 2009: Società Italiana di Immunologia, Immunologia Clinica e Allergologia,
• Dal 2014: the European Hematology Association (EHA)
• Dal 2018: American Society of Hematology (ASH)
• Dal 2019: Fondazione Italiana Linfomi (FIL)
• Dal 2025: American Association for Cancer Research (AACR)

Attività di ricerca
Al 16 Maggio 2026, Il Prof Casola ha pubblicato 69 articoli scientifici in riviste peer-reviewed. Il suo laboratorio studia i determinanti genetici e epigenetici che regolano il differenziamento e l’immunita’ mediata da linfociti B, e la loro rilevanza nella patogenesi dei linfomi a cellule B. Il Prof Casola e’ riconosciuto a livello internazionale per gli studi condotti dal suo gruppo sul ruolo del B cell receptor nella biologia , nella diagnosi e nella resistenza a terapie molecolari dei linfomi a cellule B mature. Il gruppo Casola sviluppa ed analizza modelli murini geneticamente modificati e grazie a collaborazioni con ematopatologi riconosciuti a livello internazionale studia la biologia dei linfomi umani investigando campioni bioptici tumorali di pazienti.
Dal 2006, anno in cui ha avviato la sua attività di responsabile di unità di ricerca presso IFOM, l’Istituto AIRC di Oncologia Molecolare, il Dott. Casola ha garantito in maniera continuativa al proprio gruppo finanziamenti di ricerca competitivi da enti nazionali e internazionali quali il Consiglio Europeo della Ricerca (ERC), Horizon 2020, Worldwide Cancer Research, l’Associazione Italiana per la Ricerca sul Cancro (AIRC), la Fondazione Telethon, la Fondazione Cariplo e il Ministero della Salute.

Contributi scientifici principali
• Sviluppo di modello murino per inattivazione genica condizionale in linfociti B del centro germinativo (Casola et al., PNAS 2006)
• Modelli murini per lo studio delle proteine del virus di Epstein Barr (EBV) LMP1 e LMP2A nella patogenesi dei linfomi EBV-associati (Casola et al., Nat Immunol 2004; Zhang, Casola et al., Cell 2012)
• Ruolo del miR-155 nella risposta immunitaria mediata da anticorpi (Thai et al., Science 2006)
• Ruolo di Ezh2 nella riprogrammazione cellulare e nella risposta immunitaria mediata da linfociti B (Fragola et al. 2009; Caganova et al. 2013)
• Plasticità nucleare delle plasmacellule (Kumar et al., PNAS 2015)
• Contributo di IGHV replacement nella diversificazione del repertorio anticorpale primario (Kumar et al., PNAS 2015)
• Ruolo del BCR nel linfoma di Burkitt (Varano et al., Nature 2017)
• Ruolo del BCR nella patogenesi dei linfomi ad alto grado con riarrangiamenti di MYC e BCL2 (Varano et al., Blood Cancer Discovery 2025)
• Ruolo delle proteine RAG1/2 nella patogenesi dei linfomi ad alto grado con riarrangiamenti di MYC e BCL2 ((Varano et al., Blood Cancer Discovery 2025 e Lonardi et al., Leukemia 2026)
Organizzazione di conferenze internazionali
• 2017: 19th International Conference on “Lymphatic Tissues and Germinal Centres in Immune Reactions”, San Servolo, Italy
• 2009: SEMM International Workshop on “Reprogramming Cell Fate- Basic Biology and Medical Perspectives”, Milan, Italy

Conferenze internazionali e presentazioni (2018-2026; invited speaker)
• 2026 The European Hematology Association (EHA) annual meeting, Stockholm Sweden.
• 2025 CRC 1530 Symposium, Cologne, Germany.
• 2024 ASH Annual Meeting, San Diego, CA, USA.
• 2024 Cambridge Lymphoma Biology International Symposium (CLBIS), Cambridge UK.
• 2023: 17th International Conference on Malignant Lymphoma, Lugano, Switzerland.
• 2023: The European Hematology Association (EHA) annual meeting, Frankfurt, Germany.
• 2022: EMBO Workshop on Germinal centers and immune niches; Weizmann Institute of Science, Rehovot, Israel.
• 2022: SIAPEC (Italian Society of Pathology) annual meeting, Padua, Italy.
• 2021: The European Hematology Association (EHA), 2021 virtual annual meeting: presenter Dr H. Arima on behalf of Dr Casola.
• 2020: Second AACR International Meeting on Advances in Malignant Lymphoma: Maximizing the Basic-Translational Interface for Clinical Application, Boston, USA.
• 2020: 11th Japanese Society of Hematology International Symposium, Shimane, Japan.
• 2019: European School of Hematology (ESH) 5th International Conference: New Concepts in Lymphoid Malignancies, Estoril, Portugal.
• 2019: International Workshop on Chronic Lymphocytic Leukemia (iwCLL), Edinburgh, Scotland.
• 2018: 47th Annual Meeting of the Japanese Society for Immunology, Fukuoka, Japan.
• 2018: American Society of Hematology (ASH) annual meeting, San Diego, CA, USA.
• 2018: American Society of Hematology (ASH), conference on Lymphoma Biology, Chantilly, VA, USA.

Pubblicazioni (in senso cronologico inverso)
1. Soilleux EJ, Anderson A, Roberts E, Lyne L, Wong KK, Spearman H, Casola S, Banham AH, Gascoyne DM. Vitamin D receptor expression in germinal centre type diffuse large B-cell lymphoma cells is associated with vitamin D insensitivity. Endocr Oncol. 2026 Mar 16;6(1):e250057. doi: 10.1530/EO-25-0057. PMID: 41884528;PMCID: PMC13010275.

2. Lonardi S, Cancila V, Morello G, Varano G, Balzarini P, Pellegrini V, Albertini E, Giampaolo S, Pietrini I, Thanasi H, Sindaco P, Piazza F, Manni S, Lorenzini D, Pruneri G, Dei Tos AP, Ponzoni M, Facchetti F, Pizzi M, Lorenzi L, Tripodo C, Casola S. RAG1/2 expression in IGH-switched follicular lymphoma associated with transformation to high-grade B-cell lymphoma. Leukemia. 2026 Mar 6. doi: 10.1038/s41375-026-02896-4. Epub ahead of print. PMID: 41792441.

3. Casola S, Varano G. The B-cell Receptor Blueprint in Lymphoma: Mechanisms and Therapeutic Opportunities. Blood Cancer Discov. 2026 Mar 2:OF1-OF14. doi:10.1158/2643-3230.BCD-25-0303. Epub ahead of print. PMID: 41770110.

4. Brambillasca S, Chantal Parr N, Palmeri A, Andronache A, Arima H, Faga' G, Leuzzi B, Perucho L, Robusto M, Pasi M, Mainoldi F, Fancelli D, Varasi M, Varano G, Mercurio C, Casola S. Targetable Vulnerabilities in MYC-Driven B Cell Lymphomas Resistant to BCR Extinction. Hematol Oncol. 2026 Mar;44(2):e70175.doi: 10.1002/hon.70175. PMID: 41668618; PMCID: PMC12892111

5. Cancila V, Bertolazzi G, Chan AS, Medico G, Bastianello G, Morello G, Paysan D, Lai C, Hong L, Shenoy G, Jaynes PW, Schiavoni G, Mattei F, Piconese S, Revuelta MV, Noto F, Businaro L, De Ninno A, Cammarata I, Pagni F, Venkatachalapathy S, Sangaletti S, Di Napoli A, Cicio G, Vacca D, Lonardi S, Lorenzi L, Ferreri AJ, Belmonte B, Liu M, Lakshmanan M, Ong MS, Zhang B, See T, Lam KP, Varano G, Colombo MP, Bicciato S, Inghirami G, Cerchietti L, Ponzoni M, Zappasodi R, Metzger E, Beechem J, Facchetti F, Foiani M, Casola S, Jeyasekharan AD, Tripodo C. Aggressive B cell lymphomas retain ATR-dependent determinants of T cell exclusion from the germinal center dark zone. J Clin Invest. 2025 Jul 17;135(18):e187371. doi: 10.1172/JCI187371.
6. Varano G, Lonardi S, Sindaco P, Pietrini I, Morello G, Balzarini P, Vit F, Neuman H, Bertolazzi G, Brambillasca S, Parr NC, Chiarini M, Bellesi S, Maiolo E, Giampaolo S, Mainoldi F, Selvarasa V, Arima H, Pellegrini V, Pagani C, Bugatti M, Ranise C, Taddei TM, Sonoki T, Thanasi H, Morlacchi E, Segura-Garzon D, Albertini E, Daffini R, Sivacegaram A, Yang H, Li Y, Cancila V, Cicio G, Robusto M, Leuzzi B, Andronache A, Trifiro P, Riboni M, Minardi SP, Bonnal RJP, Gonzalez CL, Visco E, Capaccio P, Torretta S, Pignataro L, Almici C, Varasi M, Larocca LM, Siebert R, Falini B, Ferreri AJM, Tucci A, Lorenzini D, Cabras AD, Pruneri G, Di Napoli A, Ungari M, Pizzi M, Hohaus S, Mercurio C, Song JY, Chan WC, Lorenzi L, Bomben R, Ponzoni M, Mehr R, Tripodo C, Facchetti F, Casola S.B cell receptor silencing reveals the origin of high-grade B cell lymphomas with MYC and BCL2 rearrangements. Blood Cancer Discov. 2025 Jul 1;6(4):364-393. doi: 10.1158/2643-3230.BCD-25-0099
7. Marcos-Kovandzic L, Avagliano M, Ben Khelil M, Srikanthan J, Abdallah R, Petrocelli V, Rengassamy J, Alfaro A, Bied M, Fidelle M, Ferrere G, Daillere R, Arbab A, Amine-Hneineh R, Pages A, Dartigues P, Ly P, Simon S, Durand S, Gottschlich A, Ginhoux F, Bleriot C, Liu P, Zhao L, Creusot L, Rolhion N, Derosa L, Kroemer G, Menger L, Kobold S, Castilla-Llorente C, Sokol H, Casola S, Pasolli E, Zitvogel L, Bigenwald C. Gut microbiota modulation through Akkermansia spp. supplementation increases CAR-T cell potency. Cancer Discov. 2025 Jun 11. doi: 10.1158/2159-8290.CD-24-1230.
8. Pizzi M, Lorenzi L, Scarmozzino F, Albertini E, Santoro L, Mussiolin L, Carraro E, Cutrone C, Casola S, Pillon M, Dei Tos AP. Reactive Bcl2-positive germinal centers in pediatric tonsils: expanding the spectrum of lymphoma mimickers in children and adolescents. Histopathology. 2025 Jul;87(1):145-152. doi: 10.1111/his.15460.
9. Raucci F, Vernieri C, Di Tano M, Ligorio F, Blaževits O, Lazzeri S, Shmahala A, Fragale G, Salvadori G, Varano G, Casola S, Buono R, Visco E, de Braud F, Longo V. Cyclic fasting-mimicking diet (FMD) plus bortezomib and rituximab as an effective treatment for Chronic Lymphocytic Leukemia (CLL). Cancer Res. 2024 Apr 1;84(7):1133-1148. doi: 10.1158/0008-5472.CAN-23-0295.
10. Hariprakash JM, Salviato E, La Mastra F, Sebestyén E, Tagliaferri I, Silva RS, Lucini F, Farina L, Cinquanta M, Rancati I, Riboni M, Minardi SP, Roz L, Gorini F, Lanzuolo C, Casola S, Ferrari F. Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer. Cancer Res. 2024 Jan 2;84(1):133-153. doi: 10.1158/0008-5472.CAN-23-1129.
11. Lorenzi L, Lonardi S, Bonezzi M, Zini S., Bugatti M., Valzelli A, Melotti F, Facchetti M, Ghini I, Villanacci V, Balzarini P, Pizzi M, Giustini V, Galvagni A. Chiarini M, Dei Tos AP, Vermi W, Casola S, Facchetti F. Immunoglobulin light chain transcript detection by ultrasensitive RNA in situ hybridization for B-cell lymphoma diagnosis Virchows Archiv. 2023 Oct 26. https://doi.org/10.1007/s00428-023-03682-8
12. Huda A , Arakawa H , Mazzucco G , Galli M , Petrocelli V , Casola S , Chen L, Doksani Y. The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Sci Adv. 2023. Mar 22;9(12):eadf2011. doi: 10.1126/sciadv.adf2011.
13. Quotti Tubi L, Mandato E, Canovas Nunes S, Arjomand A, Zaffino F, Manni S, Casellato A, Macaccaro P, Vitulo N, Zumerle S, Filhol O, Boldyreff B, Siebel CW, Viola A, Valle G, Mainoldi F, Casola S, Cancila V, Gulino A, Tripodo C, Pizzi M, Dei Tos AP, Trentin L, Semenzato G, Piazza F. CK2β-regulated signaling controls B cell differentiation and function. Front Immunol. 2023 Jan 11;13:959138. doi: 10.3389/fimmu.2022.959138.
14. Rovito R, Bono V, Augello M, Tincati C, Mainoldi F, Beaudoin-Bussières G, Tauzin A, Bianchi S, Hadla M, Yellenki V, d'Arminio Monforte A, Casola S, Borghi E, Finzi A, Marchetti G. Association between SARS-CoV-2 RNAemia and dysregulated immune response in acutely ill hospitalized COVID-19 patients. Sci Rep. 2022 Nov 16;12(1):19658. doi: 10.1038/s41598-022-23923-1..
15. Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T. EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. Commun Biol. 2022 Mar 29;5(1):280. doi: 10.1038/s42003-022-03201-6.
16. Facchetti F, Bugatti M, Drera E, Tripodo C, Sartori E, Cancila V, Papaccio M, Castellani R, Casola S, Boniotti MB, Cavadini P, Lavazza A. SARS-CoV2 vertical transmission with adverse effects on the newborn revealed through integrated immunohistochemical, electron microscopy and molecular analyses of Placenta. EBioMedicine. 2020 Sep;59:102951. doi: 10.1016/j.ebiom.2020.102951.
17. Tripodo C, Zanardi F, Iannelli F, Mazzara S, Vegliante M, Morello G, Di Napoli A, Mangogna A, Facchetti F, Sangaletti S, Chiodoni C, VanShoiack A, Jeyasekharan AD, Casola S, Colombo MP, Ponzoni M, Pileri SA. A Spatially Resolved Dark- versus Light-Zone Microenvironment Signature Subdivides Germinal Center-Related Aggressive B Cell Lymphomas. iScience. 2020 Sep 16;23(10):101562.doi: 10.1016/j.isci.2020.101562.
18. 3. Cossarizza A, Chang HD, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B, Beisker W, Benes V, Beyaert R, Blanco A, Boardman DA, Bogdan C, Borger JG, Borsellino G, Boulais PE, Bradford JA, Brenner D, Brinkman RR, Brooks AES, Busch DH, Büscher M, Bushnell TP, Calzetti F, Cameron G, Cammarata I, Cao X, Cardell SL, Casola S, Cassatella MA, Cavani A, Celada A, Chatenoud L, Chattopadhyay PK, Chow S, Christakou E, Čičin-Šain L, Clerici M, Colombo FS, Cook L, Cooke A, Cooper AM, Corbett AJ, Cosma A, Cosmi L, Coulie PG, Cumano A, Cvetkovic L, Dang VD, Dang-Heine C, Davey MS, Davies D, De Biasi S, Del Zotto G, Dela Cruz GV, Delacher M, Della Bella S, Dellabona P, Deniz G, Dessing M, Di Santo JP, Diefenbach A, Dieli F, Dolf A, Dörner T, Dress RJ, Dudziak D, Dustin M, Dutertre CA, Ebner F, Eckle SBG, Edinger M, Eede P, Ehrhardt GRA, Eich M, Engel P, Engelhardt B, Erdei A, Esser C, Everts B, Evrard M, Falk CS, Fehniger TA, Felipo-Benavent M, Ferry H, Feuerer M, Filby A, Filkor K, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frehse B, Frenette PS, Frischbutter S, Fritzsche W, Galbraith DW, Gangaev A, Garbi N, Gaudilliere B, Gazzinelli RT, Geginat J, Gerner W, Gherardin NA, Ghoreschi K, Gibellini L, Ginhoux F, Goda K, Godfrey DI, Goettlinger C, González-Navajas JM, Goodyear CS, Gori A, Grogan JL, Grummitt D, Grützkau A, Haftmann C, Hahn J, Hammad H, Hämmerling G, Hansmann L, Hansson G, Harpur CM, Hartmann S, Hauser A, Hauser AE, Haviland DL, Hedley D, Hernández DC, Herrera G, Herrmann M, Hess C, Höfer T, Hoffmann P, Hogquist K, Holland T, Höllt T, Holmdahl R, Hombrink P, Houston JP, Hoyer BF, Huang B, Huang FP, Huber JE, Huehn J, Hundemer M, Hunter CA, Hwang WYK, Iannone A, Ingelfinger F, Ivison SM, Jäck HM, Jani PK, Jávega B, Jonjic S, Kaiser T, Kalina T, Kamradt T, Kaufmann SHE, Keller B, Ketelaars SLC, Khalilnezhad A, Khan S, Kisielow J, Klenerman P, Knopf J, Koay HF, Kobow K, Kolls JK, Kong WT, Kopf M, Korn T, Kriegsmann K, Kristyanto H, Kroneis T, Krueger A, Kühne J, Kukat C, Kunkel D, Kunze-Schumacher H, Kurosaki T, Kurts C, Kvistborg P, Kwok I, Landry J, Lantz O, Lanuti P, LaRosa F, Lehuen A, LeibundGut-Landmann S, Leipold MD, Leung LYT, Levings MK, Lino AC, Liotta F, Litwin V, Liu Y, Ljunggren HG, Lohoff M, Lombardi G, Lopez L, López-Botet M, Lovett-Racke AE, Lubberts E, Luche H, Ludewig B, Lugli E, Lunemann S, Maecker HT, Maggi L, Maguire O, Mair F, Mair KH, Mantovani A, Manz RA, Marshall AJ, Martínez-Romero A, Martrus G, Marventano I, Maslinski W, Matarese G, Mattioli AV, Maueröder C, Mazzoni A, McCluskey J, McGrath M, McGuire HM, McInnes IB, Mei HE, Melchers F, Melzer S, Mielenz D, Miller SD, Mills KHG, Minderman H, Mjösberg J, Moore J, Moran B, Moretta L, Mosmann TR, Müller S, Multhoff G, Muñoz LE, Münz C, Nakayama T, Nasi M, Neumann K, Ng LG, Niedobitek A, Nourshargh S, Núñez G, O'Connor JE, Ochel A, Oja A, Ordonez D, Orfao A, Orlowski-Oliver E, Ouyang W, Oxenius A, Palankar R, Panse I, Pattanapanyasat K, Paulsen M, Pavlinic D, Penter L, Peterson P, Peth C, Petriz J, Piancone F, Pickl WF, Piconese S, Pinti M, Pockley AG, Podolska MJ, Poon Z, Pracht K, Prinz I, Pucillo CEM, Quataert SA, Quatrini L, Quinn KM, Radbruch H, Radstake TRDJ, Rahmig S, Rahn HP, Rajwa B, Ravichandran G, Raz Y, Rebhahn JA, Recktenwald D, Reimer D, Reis E Sousa C, Remmerswaal EBM, Richter L, Rico LG, Riddell A, Rieger AM, Robinson JP, Romagnani C, Rubartelli A, Ruland J, Saalmüller A, Saeys Y, Saito T, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sandrock I, Santoni A, Sanz RB, Saresella M, Sautes-Fridman C, Sawitzki B, Schadt L, Scheffold A, Scherer HU, Schiemann M, Schildberg FA, Schimisky E, Schlitzer A, Schlosser J, Schmid S, Schmitt S, Schober K, Schraivogel D, Schuh W, Schüler T, Schulte R, Schulz AR, Schulz SR, Scottá C, Scott-Algara D, Sester DP, Shankey TV, Silva-Santos B, Simon AK, Sitnik KM, Sozzani S, Speiser DE, Spidlen J, Stahlberg A, Stall AM, Stanley N, Stark R, Stehle C, Steinmetz T, Stockinger H, Takahama Y, Takeda K, Tan L, Tárnok A, Tiegs G, Toldi G, Tornack J, Traggiai E, Trebak M, Tree TIM, Trotter J, Trowsdale J, Tsoumakidou M, Ulrich H, Urbanczyk S, van de Veen W, van den Broek M, van der Pol E, Van Gassen S, Van Isterdael G, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Borstel A, von Volkmann K, Waisman A, Walker RV, Wallace PK, Wang SA, Wang XM, Ward MD, Ward-Hartstonge KA, Warnatz K, Warnes G, Warth S, Waskow C, Watson JV, Watzl C, Wegener L, Weisenburger T, Wiedemann A, Wienands J, Wilharm A, Wilkinson RJ, Willimsky G, Wing JB, Winkelmann R, Winkler TH, Wirz OF, Wong A, Wurst P, Yang JHM, Yang J, Yazdanbakhsh M, Yu L, Yue A, Zhang H, Zhao Y, Ziegler SM, Zielinski C, Zimmermann J, Zychlinsky A. Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107.
19. Casola S*, Perucho L, Tripodo C, Sindaco P, Ponzoni M, Facchetti F. The B cell receptor in control of tumor B cell fitness: biology and clinical relevance. Immunol Rev. 2019 Mar;288(1):198-213. doi: 10.1111/imr.12738.
20. Vernieri C, Pusceddu S, Fucà G, Indelicato P, Centonze G, Castagnoli, L Ferrari E, Ajazi A, Pupa S, Casola S, Foiani M, Mazzaferro V, Pruneri G, Milione M, de Braud F. Impact of systemic and tumor lipid metabolism on everolimusefficacy in advanced pancreatic neuroendocrine tumors (pNETs). Int J Cancer. 2018. Dec 5. doi: 10.1002/ijc.32042.
21. Catucci I, Osorio A, Arver B, Neidhardt G, Bogliolo M, Zanardi F, Riboni M, Minardi S, Pujol R, Azzollini J, Peissel B, Manoukian S, De Vecchi G, Casola S, Hauke J, Richters L, Rhiem K, Schmutzler RK, Wallander K, Törngren T, Borg Å,Radice P, Surrallés J, Hahnen E, Ehrencrona H, Kvist A, Benitez J, Peterlongo P. Individuals with FANCM biallelic mutations do not develop Fanconi anemia, but show risk for breast cancer, chemotherapy toxicity and may display chromosome fragility. Genet Med. 2018 Apr;20(4):452-457. doi: 10.1038/gim.2017.123
22. Petrocelli V, Casola S. Targeting Gene Function in Germinal Center B Cells: A Practical Approach. Methods Mol Biol. 2017;1623:209-231. doi:10.1007/978-1-4939-7095-7_17.
23. Varano G, Raffel S, Sormani M, Zanardi F, Lonardi S, Zasada C, Perucho L,Petrocelli V, Haake A, Lee AK, Bugatti M, Paul U, Van Anken E, Pasqualucci L, Rabadan R, Siebert R, Kempa S, Ponzoni M, Facchetti F, Rajewsky K, Casola S. The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition. Nature. 2017 Jun 8;546(7657):302-306. doi: 10.1038/nature22353.
24. Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S*, Waisman A*, Kurschus FC*. EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell Rep. 2017 Jan 31;18(5):1270-1284. doi: 10.1016/j.celrep.2017.01.020.
25. Vernieri C, Casola S, Foiani M, Pietrantonio F, de Braud F, Longo V. Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. Cancer Discov. 2016 Dec;6(12):1315-1333. doi: 10.1158/2159-8290.CD-16-0615.
26. Mihailovich M, Bremang M, Spadotto V, Musiani D, Vitale E, Varano G, Zambelli F, Mancuso FM, Cairns DA, Pavesi G, Casola S, Bonaldi T. miR-17-92 fine-tunes MYC expression and function to ensure optimal B cell lymphoma growth. Nat Commun. 2015 Nov 10; 6:8725. doi: 10.1038/ncomms9725.
27. Kumar R, Bach MP, Mainoldi F, Maruya M, Kishigami S, Jumaa H, Wakayama T, Kanagawa O, Fagarasan S, Casola S. Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E450-7. doi: 10.1073/pnas.1417988112.
28. Alberghini F, Petrocelli V, Rahmat M, Casola S. An epigenetic view of B-cell disorders. Immunol Cell Biol. 2015 Mar; 93(3):253-60. doi: 10.1038/icb.2014.116. Epub 2015 Jan 20.
29. Simonetti G, Bertilaccio MT, Rodriguez TV, Apollonio B, Dagklis A, Rocchi M, Innocenzi A, Casola S, Winkler TH, Nitschke L, Ponzoni M, Caligaris-Cappio F, Ghia P. SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders. Haematologica. 2014 Aug;99(8):1356-64. doi: 10.3324/haematol.2013.100230.
30. Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D. Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication. Nat Commun. 2014 Apr 14;5: 3649. doi: 10.1038/ncomms4649.
31. Colombo E, Tentorio P, Musio S, Rajewsky K, Pedotti R, Casola S, Farina C. Skewed B cell differentiation affects lymphoid organogenesis but not T cell-mediated autoimmunity. Clin Exp Immunol. 2014 Apr;176(1):58-65. doi: 10.1111/cei.12250.
32. Caganova M, Carrisi C, Varano G, Mainoldi F, Zanardi F, Germain PL, George L, Alberghini F, Ferrarini L, Talukder AK, Ponzoni M, Testa G, Nojima T, Doglioni C, Kitamura D, Toellner KM, Su IH, Casola S. Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis. J Clin Invest. 2013 Dec;123(12):5009-22. doi: 10.1172/JCI70626. Epub 2013 Nov 8. Erratum in: J Clin Invest. 2014 Apr 1;124(4):1869.
33. Fogli LK, Sundrud MS, Goel S, Bajwa S, Jensen K, Derudder E, Sun A, Coffre M, Uyttenhove C, Van Snick J, Schmidt-Supprian M, Rao A, Grunig G, Durbin J, Casola S, Rajewsky K, Koralov SB. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol. 2013 Sep 15;191(6):3100-11. doi: 10.4049/jimmunol.1301360. Epub 2013 Aug 21. Erratum in: J Immunol. 2013 Nov 15;191(10):5318. Casola, Stefano S [corrected to Casola, Stefano].
34. Fragola G, Germain PL, Laise P, Cuomo A, Blasimme A, Gross F, Signaroldi E, Bucci G, Sommer C, Pruneri G, Mazzarol G, Bonaldi T, Mostoslavsky G, Casola S*, Testa G*. Cell reprogramming requires silencing of a core subset of polycomb targets. PLoS Genet. 2013;9(2):e1003292. doi: 10.1371/journal.pgen.1003292.
35. Pengo N, Scolari M, Oliva L, Milan E, Mainoldi F, Raimondi A, Fagioli C, Merlini A, Mariani E, Pasqualetto E, Orfanelli U, Ponzoni M, Sitia R, Casola S, Cenci S. Plasma cells require autophagy for sustainable immunoglobulin production. Nat Immunol. 2013 Mar;14(3):298-305. doi: 10.1038/ni.2524.
36. Lechouane F, Bonaud A, Delpy L, Casola S, Oruc Z, Chemin G, Cogné M, Sirac C. B-cell receptor signal strength influences terminal differentiation. Eur J Immunol. 2013 Mar;43(3):619-28. doi: 10.1002/eji.201242912.
37. Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Betsholtz IH, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N. The endocytic adaptor Eps15 controls marginal zone B cell numbers. PLoS One. 2012;7(11):e50818. doi: 10.1371/journal.pone.0050818.
38. Burgold T, Voituron N, Caganova M, Tripathi PP, Menuet C, Tusi BK, Spreafico F, Bévengut M, Gestreau C, Buontempo S, Simeone A, Kruidenier L, Natoli G, Casola S, Hilaire G, Testa G. The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival. Cell Rep. 2012 Nov 29;2(5):1244-58. doi: 10.1016/j.celrep.2012.09.013.
39. Zhang B**, Kracker S**, Yasuda T**, Casola S**, Vanneman M, Hömig-Hölzel C, Wang Z, Derudder E, Li S, Chakraborty T, Cotter SE, Koyama S, Currie T, Freeman GJ, Kutok JL, Rodig SJ, Dranoff G, Rajewsky K. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell. 2012 Feb 17;148(4):739-51. doi: 10.1016/j.cell.2011.12.031.
40. Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T. The LRF transcription factor regulates mature B cell development and the germinal center response in mice. J Clin Invest. 2011 Jul;121(7):2583-98. doi: 10.1172/JCI45682.
41. Pasi CE, Dereli-Öz A, Negrini S, Friedli M, Fragola G, Lombardo A, Van Houwe G, Naldini L, Casola S, Testa G, Trono D, Pelicci PG, Halazonetis TD. Genomic instability in induced stem cells. Cell Death Differ. 2011 May;18(5):745-53. doi: 10.1038/cdd.2011.9.
42. Casola S. Mouse models for miRNA expression: the ROSA26 locus. Methods Mol Biol. 2010;667: 145-63. doi: 10.1007/978-1-60761-811-9_10.
43. Grazini U, Zanardi F, Citterio E, Casola S, Goding CR, McBlane F. The RING domain of RAG1 ubiquitylates histone H3: a novel activity in chromatin-mediated regulation of V(D)J joining. Mol Cell. 2010 Jan 29;37(2):282-93. doi: 10.1016/j.molcel.2009.12.035.
44. Omodei D, Acampora D, Russo F, De Filippi R, Severino V, Di Francia R, Frigeri F, Mancuso P, De Chiara A, Pinto A, Casola S, Simeone A. Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma. Am J Pathol. 2009 Dec;175(6):2609-17. doi: 10.2353/ajpath.2009.090542.
45. De Santa F, Narang V, Yap ZH, Tusi BK, Burgold T, Austenaa L, Bucci G, Caganova M, Notarbartolo S, Casola S, Testa G, Sung WK, Wei CL, Natoli G. Jmjd3 contributes to the control of gene expression in LPS-activated macrophages. EMBO J. 2009 Nov 4;28(21):3341-52. doi: 10.1038/emboj.2009.271.
46. Hikida M, Casola S, Takahashi N, Kaji T, Takemori T, Rajewsky K, Kurosaki T. PLC-gamma2 is essential for formation and maintenance of memory B cells. J Exp Med. 2009 Mar 16;206(3):681-9. doi: 10.1084/jem.20082100.
47. Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity. 2008 Oct 17;29(4):615-27. doi: 10.1016/j.immuni.2008.07.016.
48. Hömig-Hölzel C, Hojer C, Rastelli J, Casola S, Strobl LJ, Müller W, Quintanilla-Martinez L, Gewies A, Ruland J, Rajewsky K, Zimber-Strobl U. Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29. doi: 10.1084/jem.20080238.
49. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27;316(5824):604-8. doi: 10.1126/science.1141229.
50. Casola S. Control of peripheral B-cell development. Curr Opin Immunol. 2007 Apr;19(2):143-9. doi: 10.1016/j.coi.2007.02.010.
51. Casola S, Rajewsky K. B cell recruitment and selection in mouse GALT germinal centers. Curr Top Microbiol Immunol. 2006;308: 155-71. doi: 10.1007/3-540-30657-9_7.
52. Klein U, Casola S, Cattoretti G, Shen Q, Lia M, Mo T, Ludwig T, Rajewsky K, Dalla-Favera R. Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006 Jul;7(7):773-82. doi: 10.1038/ni1357.
53. Casola S, Cattoretti G, Uyttersprot N, Koralov SB, Seagal J, Hao Z, Waisman A, Egert A, Ghitza D, Rajewsky K. Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7396-401. doi: 10.1073/pnas.0602353103.
54. Novobrantseva TI, Majeau GR, Amatucci A, Kogan S, Brenner I, Casola S, Shlomchik MJ, Koteliansky V, Hochman PS, Ibraghimov A. Attenuated liver fibrosis in the absence of B cells. J Clin Invest. 2005 Nov;115(11):3072-82. doi: 10.1172/JCI24798.
55. Sasaki Y, Casola S, Kutok JL, Rajewsky K, Schmidt-Supprian M. TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology. J Immunol. 2004 Aug 15;173(4):2245-52. doi: 10.4049/jimmunol.173.4.2245.
56. Schmidt-Supprian M, Tian J, Ji H, Terhorst C, Bhan AK, Grant EP, Pasparakis M, Casola S, Coyle AJ, Rajewsky K. I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion. J Immunol. 2004 Aug 1;173(3):1612-9. doi: 10.4049/jimmunol.173.3.1612.
57. Casola S. Conditional gene mutagenesis in B-lineage cells. Methods Mol Biol. 2004;271: 91-109. doi: 10.1385/1-59259-796-3:091.
58. Casola S, Otipoby KL, Alimzhanov M, Humme S, Uyttersprot N, Kutok JL, Carroll MC, Rajewsky K. B cell receptor signal strength determines B cell fate. Nat Immunol. 2004 Mar;5(3):317-27. doi: 10.1038/ni1036.
59. Vernucci M, Cerrato F, Besnard N, Casola S, Pedone PV, Bruni CB, Riccio A. The H19 endodermal enhancer is required for Igf2 activation and tumor formation in experimental liver carcinogenesis. Oncogene. 2000 Dec 14;19(54):6376-85. doi: 10.1038/sj.onc.1204024.
60. Sperandeo MP, Ungaro P, Vernucci M, Pedone PV, Cerrato F, Perone L, Casola S, Cubellis MV, Bruni CB, Andria G, Sebastio G, Riccio A. Relaxation of insulin-like growth factor 2 imprinting and discordant methylation at KvDMR1 in two first cousins affected by Beckwith-Wiedemann and Klippel-Trenaunay-Weber syndromes. Am J Hum Genet. 2000 Mar;66(3):841-7. doi: 10.1086/302811.
61. Ungaro P, Casola S, Vernucci M, Pedone PV, Bruni CB, Riccio A. Relaxation of insulin-like growth factor-2 imprinting in rat cultured cells. Mol Cell Endocrinol. 1997 Dec 12;135(2):153-63. doi: 10.1016/s0303-7207(97)00201-3.
62. Casola S, Pedone PV, Cavazzana AO, Basso G, Luksch R, d'Amore ES, Carli M, Bruni CB, Riccio A. Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma. Oncogene. 1997 Mar 27;14(12):1503-10. doi: 10.1038/sj.onc.1200956.
63. Zarrilli R, Romano M, Pignata S, Casola S, Bruni CB, Acquaviva AM. Constitutive insulin-like growth factor-II expression interferes with the enterocyte-like differentiation of CaCo-2 cells. J Biol Chem. 1996 Apr 5;271(14):8108-14. PMID: 8626497. doi: 10.1074/jbc.271.14.8108.
64. Casola S, Vernucci M, Ungaro P, Bruni CB, Riccio A. Preferential loss of heterozygosity of chromosome 7 loci in simian virus 40 t/T antigen-induced mouse hepatocellular carcinomas does not involve H-ras mutations. Acta Genet Med Gemellol. 1996;45(1-2):221-5. doi: 10.1017/s0001566000001343.
65. Casola S, Ungaro P, Pedone PV, Lazzaro D, Fattori E, Ciliberto G, Zarrilli R, Bruni CB, Riccio A. Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas. Oncogene. 1995 Aug 17;11(4):711-21. PMID: 7651735.
66. Zarrilli R, Pignata S, Romano M, Gravina A, Casola S, Bruni CB, Acquaviva AM. Expression of insulin-like growth factor (IGF)-II and IGF-I receptor during proliferation and differentiation of CaCo-2 human colon carcinoma cells. Cell Growth Differ. 1994 Oct;5(10):1085-91. PMID: 7848910.
67. Boisclair YR, Brown AL, Casola S, Rechler MM. Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat. J Biol Chem. 1993 Nov 25;268(33):24892-901. PMID: 7693708.
68. Zarrilli R, Casola S, Conti A, Bruni CB, Colantuoni V. Extinction of insulin-like growth factor II gene expression in intratypic hybrids of rat liver cells. Mol Endocrinol. 1993 Jan;7(1):131-41. doi: 10.1210/mend.7.1.8446103.
69. Zarrilli R, Colantuoni V, Faraonio R, Casola S, Rossi E, Bruni CB. Extinction of human insulin-like growth factor II expression in somatic cell hybrids. Adv Exp Med Biol. 1991; 293:77-83. doi: 10.1007/978-1-4684-5949-4_7.