LANDSBERGER NICOLETTA

Parole Chiave (3)

EPIGENETICA

MALATTIE DEL NEUROSVILUPPO

TRASCRIZIONE

Ricerca Finanziata (2)

Exploiting computational biology for target identification and drug repositioning in CDKL5 disorder.

INTLI - Finanziamenti internazionali

Project

2016

Novel approaches of "personalized medicine" as proof of principle for CDKL5 related pathologies.

INTLI - Finanziamenti internazionali

Project

2015

No Results Found

Premi E Riconoscimenti (2)

Commendatore Ordine al Merito della Repubblica Italiana, conferito da Presidente della Repubblica Italiana

2011

NIH Fellows Award for Research Excellence, 1995, conferito da National Institute of Health

1997

No Results Found

Partecipazioni Scientifiche (2)

Fellow (riconoscimento scientifico) - Società Italiana Neuro-Scienze (SINS) (Italia) (2012 - 2015)

Fellow (riconoscimento scientifico) - Società Italiana Biofisica e Biologia Molecolare (SIBBM) (Italia) (2007 - 2012)

No Results Found

Collegi Di Dottorato (15)

Università degli Studi di MILANO - MEDICINA SPERIMENTALE-2019 (ciclo: 35 - Anno: 2019 )

Università degli Studi di MILANO - MEDICINA SPERIMENTALE-2018 (ciclo: 34 - Anno: 2018 )

Università degli Studi di MILANO - MEDICINA SPERIMENTALE E BIOTECNOLOGIE MEDICHE-2017 (ciclo: 33 - Anno: 2017 )

Università degli Studi di MILANO - MEDICINA SPERIMENTALE E BIOTECNOLOGIE MEDICHE-2016 (ciclo: 32 - Anno: 2016 )

Università degli Studi di MILANO - MEDICINA SPERIMENTALE E BIOTECNOLOGIE MEDICHE-2015 (ciclo: 31 - Anno: 2015 )

Università degli Studi INSUBRIA Varese-Como - MEDICINA SPERIMENTALE E TRASLAZIONALE-2014 (ciclo: 30 - Anno: 2014 )

Università degli Studi INSUBRIA Varese-Como - MEDICINA SPERIMENTALE E TRASLAZIONALE-2013 (ciclo: 29 - Anno: 2013 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2012 (ciclo: 28 - Anno: 2012 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2011 (ciclo: 27 - Anno: 2011 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2010 (ciclo: 26 - Anno: 2010 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2009 (ciclo: 25 - Anno: 2009 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2008 (ciclo: 24 - Anno: 2008 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2007 (ciclo: 23 - Anno: 2007 )

Università degli Studi INSUBRIA Varese-Como - NEUROBIOLOGIA-2006 (ciclo: 22 - Anno: 2006 )

Università degli Studi INSUBRIA Varese-Como - BIOLOGIA CELLULARE E MOLECOLARE-2006 (ciclo: 22 - Anno: 2006 )

No Results Found

Tutoraggio (6)

tutorship - Assegnisti - FRASCA ANGELISA (01/03/2019 - 28/02/2021)

tutorship - Dottorandi - ALBIZZATI ELENA (01/10/2017 - )

tutorship - Assegnisti - SPIOMBI ELEONORA (01/09/2017 - 31/08/2018)

tutorship - Assegnisti - GIORGIO DOMENICO (01/07/2017 - 30/06/2018)

tutorship - Assegnisti - FRASCA ANGELISA (01/02/2016 - 31/01/2017)

tutorship - Dottorandi - FAZZARI MARIA (01/11/2014 - 19/02/2018)

No Results Found

Public Engagement (5)

Attività di coinvolgimento e interazione con il mondo della scuola (Organizzatore) - Settimana da Bio L.I.T.A Segrate (02/09/2019 - 06/09/2019)

Partecipazioni attive a incontri pubblici organizzati da altri soggetti (*) (Altro) - CDKL5 Alliance 5th International Research and Family Conference Royal college of Surgeons Edinburgh, UK (22/06/2019 - 23/06/2019)

Attività di coinvolgimento e interazione con il mondo della scuola (Altro) - La ricerca biomedica raccontata attraverso la sindrome di Rett Settore didattico Via Celoria (19/06/2019 - )

Partecipazioni attive a incontri pubblici organizzati da altri soggetti (*) (Altro) - Una nuova terapia cellulare per la sindrome di Rett Mantova, Palazzo Ducale (23/03/2019 - )

Attività di coinvolgimento e interazione con il mondo della scuola (Altro) - Le nuove frontiere della ricerca: ciclo di conferenze rivolte a docenti e studenti Settore didattico di via Celoria (13/03/2019 - )

No Results Found

Pdf

https://work.unimi.it/chiedove/cv/nicoletta_landsberger.pdf

Orcid Id

http://orcid.org/0000-0003-0820-3155

Parole Chiave (3)

Ricerca Finanziata (2)

Exploiting computational biology for target identification and drug repositioning in CDKL5 disorder.

Novel approaches of "personalized medicine" as proof of principle for CDKL5 related pathologies.

Pubblicazioni (31)

Aminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity.

Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice.

Progress in the development of in vivo redox measurements: New tools for longitudinal studies in Rett syndrome.

Rescue of prepulse inhibition deficit and brain mitochondrial dysfunction by pharmacological stimulation of the central serotonin receptor 7 in a mouse model of CDKL5 Deficiency Disorder.

Towards a consensus on developmental regression.

Tyr120Asp mutation alters domain flexibility and dynamics of MeCP2 DNA binding domain leading to impaired DNA interaction : Atomistic characterization of a Rett syndrome causing mutation.

CDKL5 localizes at the centrosome and midbody and is required for faithful cell division.

The neurosteroid pregnenolone reverts microtubule derangement induced by the loss of a functional CDKL5-IQGAP1 complex.

ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.

Brain phosphorylation of MeCP2 at serine 164 is developmentally regulated and globally alters its chromatin association.

CDKL5 and shootin1 interact and concur in regulating neuronal polarization.

Characterisation of CDKL5 Transcript Isoforms in Human and Mouse.

MeCP2 Related Studies Benefit from the Use of CD1 as Genetic Background.

Defects During Mecp2 Null Embryonic Cortex Development Precede the Onset of Overt Neurological Symptoms.

LSD1 neurospecific alternative splicing controls neuronal excitability in mouse models of epilepsy.

MeCP2 affects skeletal muscle growth and morphology through non cell-autonomous mechanisms.

Methyl-CpG binding protein 2 (MeCP2) localizes at the centrosome and is required for proper mitotic spindle organization.

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?.

Rett syndrome and the urge of novel approaches to study MeCP2 functions and mechanisms of action.

Autocrine and immune cell-derived BDNF in human skeletal muscle : implications for myogenesis and tissue regeneration.

A novel transcript of cyclin-dependent kinase-like 5 (CDKL5) has an alternative C-terminus and is the predominant transcript in brain.

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.

Extrasynaptic N-methyl-D-aspartate (NMDA) receptor stimulation induces cytoplasmic translocation of the CDKL5 kinase and its proteasomal degradation.

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a rett syndrome animal model.

CDKL5 influences RNA splicing activity by its association to the nuclear speckle molecular machinery.

Spatio-temporal dynamics and localization of MeCP2 and pathological mutants in living cells.

CDKL5 belongs to the same molecular pathway of MeCP2 and it is responsible for the early-onset seizure variant of Rett syndrome.

Retinoic acid receptor alpha fusion to PML affects its transcriptional and chromatin-remodeling properties.

Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.

NOVEL APPROACHES OF ¿PERSONALISED MEDICINE¿ AS PROOF-OF-PRINCIPLE FOR CDKL5-RELATED PATHOLOGIES.

NOVEL APPROACHES OF ¿PERSONALISED MEDICINE¿ AS PROOF-OF-PRINCIPLE FOR CDKL5-RELATED PATHOLOGIES.

Premi E Riconoscimenti (2)

Partecipazioni Scientifiche (2)

Collegi Di Dottorato (15)

Tutoraggio (6)

Public Engagement (5)

Pdf

Orcid Id