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Tumor-targeting peptidomimetics: synthesis and bio-medical applications

Project
  • Academic Signature
  • Overview
  • Publications

Academic Signature

Il servizio di classificazione ACADEMIC SIGNATURE è IN BETA TESTING e i risultati potrebbero non essere corretti

Academic Signature

Peptidomimetics
Molecular Mechanisms of Pharmacological Action

Overview

Departments involved

Dipartimento di Chimica   Principale  

Type

PRIN2015 - PRIN bando 2015

Funder

MINISTERO DELL'ISTRUZIONE E DEL MERITO
External Organization Funding Organization

Date/time interval

February 5, 2017 - February 4, 2020

Project duration

36 months

Publications

Outputs (13)

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  • Academic Article
A Trifunctional Self-Immolative Spacer Enables Drug Release with Two Non-Sequential Enzymatic Cleavages 
CHEMICAL COMMUNICATIONS
ROYAL SOCIETY OF CHEMISTRY
2021
Academic Article
Reserved Access
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Fast Cyclization of a Proline-Derived Self-Immolative Spacer Improves the Efficacy of Carbamate Prodrugs 
ANGEWANDTE CHEMIE. INTERNATIONAL EDITION
WILEY
2020
Academic Article
Reserved Access
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Multimeric Presentation of RGD Peptidomimetics Enhances Integrin Binding and Tumor Cell Uptake 
CHEMISTRY-A EUROPEAN JOURNAL
WILEY
2020
Academic Article
Partially Open Access
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A dimeric bicyclic RGD ligand displays enhanced integrin binding affinity and strong biological effects on U-373 MG glioblastoma cells 
ORGANIC & BIOMOLECULAR CHEMISTRY
ROYAL SOCIETY OF CHEMISTRY
2019
Academic Article
Partially Open Access
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Exploring E-cadherin-peptidomimetics interaction using NMR and computational studies 
PLOS COMPUTATIONAL BIOLOGY
PUBLIC LIBRARY OF SCIENCE
2019
Academic Article
Open Access
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Innovative linker strategies for tumor‐targeted drug conjugates 
CHEMISTRY-A EUROPEAN JOURNAL
WILEY BLACKWELL SCIENCE
2019
Academic Article
Partially Open Access
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Stereoselective Synthesis of α,α’-Dihydroxy-β,β’-diaryl-β-amino Acids by Mannich-like Condensation of Hydroarylamides 
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
WILEY BLACKWELL SCIENCE
2019
Academic Article
Open Access
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Stereodivergent Synthesis of 5-Aminopipecolic Acids and Application in the Preparation of a Cyclic RGD Peptidomimetic as a nanomolar αVβ3 Integrin Ligand 
ORGANIC & BIOMOLECULAR CHEMISTRY
ROYAL SOCIETY OF CHEMISTRY
2018
Academic Article
Partially Open Access
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Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and αVβ3-Integrin Ligands for Tumor Targeting 
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
WILEY
2018
Academic Article
Partially Open Access
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4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents 
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ELSEVIER
2017
Academic Article
Reserved Access
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Insights into the Binding of Cyclic RGD Peptidomimetics to a5b1 Integrin by using Live-Cell NMR And Computational Studies 
CHEMISTRYOPEN
WILEY
2017
Academic Article
Open Access
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Synthesis and conformational analysis of peptides embodying 2,3-methanopipecolic acids 
ORGANIC & BIOMOLECULAR CHEMISTRY
ROYAL SOCIETY OF CHEMISTRY
2017
Academic Article
Partially Open Access
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Targeting Integrin alpha(V)beta(3) with Theranostic RGD-Camptothecin Conjugates Bearing a Disulfide Linker: Biological Evaluation Reveals a Complex Scenario 
CHEMISTRYSELECT
WILEY VCH
2017
Academic Article
Partially Open Access
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