Program-Material is a research and innovation staff exchange network dedicated to pushing the boundaries of nanomaterials and nanotechnologies by introducing integrated protein-controlled behaviors. Our primary goal is to craft hybrid nanostructured materials featuring precise structural, functional, and spatiotemporal behaviors directly regulated by specific proteins. By incorporating synthetic biology components, these materials will demonstrate the ability to perform tailored chemical or biological functions, guided by specific proteins. This innovation holds tremendous potential for groundbreaking applications in biomedical and healthcare contexts. While traditional approaches focus on engineering nanomaterial properties to influence biological entities, Program-Material pioneers bio-based control over nanomaterial properties, emphasizing programmable influences of biomolecules—particularly proteins. Program-Material seeks to cultivate a new generation of scientists at the intersection of materials science and biotechnology. This expertise will drive innovative solutions in advanced healthcare nanomaterials, fostering unprecedented interactions with biology, particularly in precision and nanomedicine applications. To achieve these ambitious goals, we have united 9 academic partners and 1 non-academic partner in a collaborative network. This team spans European and extra-EU institutions (USA, Australia, Argentina, Switzerland, Japan) and encompasses individuals ranging from PhD candidates to experienced researchers. Our diverse composition ensures Program-Material's robust interdisciplinary and intersectoral dimension, vital for a broad and effective impact. The program places a strong emphasis on actively involving young professors, providing pivotal support for their career progression. Knowledge transfer and associated training activities are crafted to equip scientists with specific competencies in materials science, bionanotechnology, and nanomedicine.