The Human Brain Project (HBP) is a major European scientific research initiative to improve our understanding of the
brain and the role it plays in making us human, and to exploit the opportunities offered by the resulting knowledge.
The size and complexity of the brain make this an expensive undertaking, but the costs associated with our current
ignorance are rising and the potential gains from better insight into the brain are increasing. Brain-related diseases,
many of which are age-related, now represent a major part of the global health burden and there are both ethical
and economic imperatives to keep the growing number of older people healthier and more productive. Economic
advantage is increasingly linked to artificial intelligence (AI), our ability to create technology to extract, manipulate
and harness knowledge. The HBP’s comprehension of what makes the human brain so efficient and flexible should
help to maintain Europe’s competitiveness and innovation potential in this area.
The HBP is one of several brain research initiatives and projects around the world, albeit one of the first, but it is
unique in a number of ways. Only the HBP has an explicit focus on both neuroscience and computing. It is also the
broadest and most integrated brain initiative, and the only one aiming to build a research infrastructure to accelerate
brain research.
The HBP is a FET Flagship which started under FP7 and continues under H2020 with a succession of Specific Grant
Agreements (SGAs) under a Framework Partnership Agreement (FPA). In its FP7 Ramp-Up Phase (2013-16) and
subsequent SGA1 funding period (2016-18), the HBP implemented a scientific project of rare ambition, breadth
and scale, and forged its diverse constituents into a functioning entity. On the scientific side, it not only identified
critical gaps in our understanding of the brain, but also created tools and obtained data to fill many of them. It
designed, built and demonstrated six ICT research platforms, supporting neuroinformatics, brain simulation, highperformance
analytics and computing, medical informatics, brain-inspired computing and linking of simulated brains
to robotic bodies. The results have been made available to the scientific community. The HBP also learnt to address
underperformance and conflicts, and opened up the Project via competitive calls and the integration of Partnering
Projects.
In the upcoming SGA2 funding period (2018-20), the HBP will continue to strengthen global brain research efforts by
extending coordination with other brain initiatives and projects. Internally, it will continue its unique inter-disciplinary
co-design approach, developing research infrastructure capabilities via use cases built around specific research
needs. This approach will underpin its critical scientific work of understanding how to bridge between the different
scales of brain organisation, a key prerequisite to understand the principles of brain organisation. It will include
gathering data to support detailed modelling, notably of the human hippocampus, as well as structural, functional
and connectivity data to improve systemic understanding of the whole brain. The HBP will also investigate brain
similarities and differences between individuals and between species. It will model key brain functions, including
visual recognition, slow-wave activity, episodic memory and consciousness in rodents and humans, and elaborate their
cognitive architectures. In addition, it will develop simplified brain models to support further development of braininspired
computing.
SGA2 will see the individual infrastructure platforms extended and integrated into the HBP Joint Platform (HBPJP).
The JP will make HBP services more robust and improve the user experience, encouraging wider use of its tools.
SGA2 should thus see a shift from supplier-driven to user-driven capabilities, while the infrastructure underpinning
hem will be tied closely into EU efforts to integrate and strengthen HPAC capabilities to support broad range
of scientific needs such as PRACE. The HBP will prepare researchers to harness future novel and extreme-scale
computing resources to their scientific work, while allowing them shape the design of those resources. In this way,
emerging brain-inspired AI will be driven by better neuroscientific insights, dramatically improving our ability to
replicate the functionalities of the brain and understand its connectional architecture. In particular, emulating the
brain’s ability to learn will enable a major advancement over current deep learning approaches.
SGA2 should also see the introduction of a separate Legal Entity, to serve as a nucleus around which the research
infrastructure created by the HBP can coalesce, and thereby ensure that it can continue to help advance neuroscience,
medicine and neuro-inspired technology in Europe after the end of the EU project.
brain and the role it plays in making us human, and to exploit the opportunities offered by the resulting knowledge.
The size and complexity of the brain make this an expensive undertaking, but the costs associated with our current
ignorance are rising and the potential gains from better insight into the brain are increasing. Brain-related diseases,
many of which are age-related, now represent a major part of the global health burden and there are both ethical
and economic imperatives to keep the growing number of older people healthier and more productive. Economic
advantage is increasingly linked to artificial intelligence (AI), our ability to create technology to extract, manipulate
and harness knowledge. The HBP’s comprehension of what makes the human brain so efficient and flexible should
help to maintain Europe’s competitiveness and innovation potential in this area.
The HBP is one of several brain research initiatives and projects around the world, albeit one of the first, but it is
unique in a number of ways. Only the HBP has an explicit focus on both neuroscience and computing. It is also the
broadest and most integrated brain initiative, and the only one aiming to build a research infrastructure to accelerate
brain research.
The HBP is a FET Flagship which started under FP7 and continues under H2020 with a succession of Specific Grant
Agreements (SGAs) under a Framework Partnership Agreement (FPA). In its FP7 Ramp-Up Phase (2013-16) and
subsequent SGA1 funding period (2016-18), the HBP implemented a scientific project of rare ambition, breadth
and scale, and forged its diverse constituents into a functioning entity. On the scientific side, it not only identified
critical gaps in our understanding of the brain, but also created tools and obtained data to fill many of them. It
designed, built and demonstrated six ICT research platforms, supporting neuroinformatics, brain simulation, highperformance
analytics and computing, medical informatics, brain-inspired computing and linking of simulated brains
to robotic bodies. The results have been made available to the scientific community. The HBP also learnt to address
underperformance and conflicts, and opened up the Project via competitive calls and the integration of Partnering
Projects.
In the upcoming SGA2 funding period (2018-20), the HBP will continue to strengthen global brain research efforts by
extending coordination with other brain initiatives and projects. Internally, it will continue its unique inter-disciplinary
co-design approach, developing research infrastructure capabilities via use cases built around specific research
needs. This approach will underpin its critical scientific work of understanding how to bridge between the different
scales of brain organisation, a key prerequisite to understand the principles of brain organisation. It will include
gathering data to support detailed modelling, notably of the human hippocampus, as well as structural, functional
and connectivity data to improve systemic understanding of the whole brain. The HBP will also investigate brain
similarities and differences between individuals and between species. It will model key brain functions, including
visual recognition, slow-wave activity, episodic memory and consciousness in rodents and humans, and elaborate their
cognitive architectures. In addition, it will develop simplified brain models to support further development of braininspired
computing.
SGA2 will see the individual infrastructure platforms extended and integrated into the HBP Joint Platform (HBPJP).
The JP will make HBP services more robust and improve the user experience, encouraging wider use of its tools.
SGA2 should thus see a shift from supplier-driven to user-driven capabilities, while the infrastructure underpinning
hem will be tied closely into EU efforts to integrate and strengthen HPAC capabilities to support broad range
of scientific needs such as PRACE. The HBP will prepare researchers to harness future novel and extreme-scale
computing resources to their scientific work, while allowing them shape the design of those resources. In this way,
emerging brain-inspired AI will be driven by better neuroscientific insights, dramatically improving our ability to
replicate the functionalities of the brain and understand its connectional architecture. In particular, emulating the
brain’s ability to learn will enable a major advancement over current deep learning approaches.
SGA2 should also see the introduction of a separate Legal Entity, to serve as a nucleus around which the research
infrastructure created by the HBP can coalesce, and thereby ensure that it can continue to help advance neuroscience,
medicine and neuro-inspired technology in Europe after the end of the EU project.