BIOFLOW: an innovative platform for the in-flow biocatalytic preparation of high value chemicals

Project
L’obiettivo centrale di BIOFLOW è lo sviluppo di una piattaforma biotecnologica per la preparazione di prodotti chimici ad alto valore aggiunto (farmaci o loro intermedi), mediante processi efficienti, facilmente scalabili ed eco-sostenibili. Il progetto si baserà sull’utilizzo in flow di bioreattori costituiti da nucleoside fosforilasi e ω-transaminasi, opportunamente supportate, per la sintesi di nucleosidi modificati o ammine chirali, intermedi chiave per l’ottenimento di farmaci

Overview

Contributors

CONTI PAOLA   Scientific Manager  

Departments involved

Type

CAR_RIC - Bandi Fondazione Cariplo

Funder

FONDAZIONE CARIPLO
External Organization Funding Organization

Date/time interval

June 1, 2017 - May 31, 2019

Project duration

24 months

Publications

Outputs (3)

An enzymatic flow-based preparative route to vidarabine 
MOLECULES
MDPI
2020
Academic Article
Open Access
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Immobilized enzyme reactors based on nucleoside phosphorylases and 2′-deoxyribosyltransferase for the in-flow synthesis of pharmaceutically relevant nucleoside analogues 
BIORESOURCE TECHNOLOGY
ELSEVIER
2020
Academic Article
Partially Open Access
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Development of an integrated chromatographic system for ω-transaminase-IMER characterization useful for flow-chemistry applications 
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
ELSEVIER
2019
Academic Article
Partially Open Access
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