Structural investigation of proapoptotic peptide by CD and NMR spectroscopy

Academic Article
Publication Date:
2003
Citation:
Structural investigation of proapoptotic peptide by CD and NMR spectroscopy / E. Pulsinelli, F. Vasile, L. Vergani, S. Parodi, C. Nicolini. - In: PROTEIN AND PEPTIDE LETTERS. - ISSN 0929-8665. - 10:6(2003), pp. 541-549.
abstract:
We have performed a systematic investigation of the structural features of the peptides Int (a sequence able to cross cell membranes) and Int-H1(S6A, F8A) (which shows interesting antitumoral properties). After screening in aqueous solution at different ionic strength and pH values, we analyzed the structures of the peptides in different water/trifluoroethanol mixtures by Circular Dichroism and Nuclear Magnetic Resonance techniques.
IRIS type:
01 - Articolo su periodico
Keywords:
proapoptotic sequence; internalization sequence; circular dichroism; NMR spectroscopy; molecular dynamics; trifluoroethanol
List of contributors:
Authors of the University:
Link to information sheet:
https://air.unimi.it/handle/2434/721036

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Settore CHIM/06 - Chimica Organica