L’aldosterone breakthrough nel cane con malattia mitralica : revisione della letteratura = Aldosterone breakthrough in dogs with mitral valve disease : a review of the literature

Renin angiotensin aldosterone system activation represents one of the main compensatory mechanism of heart failure and it is essential to keep an adequate cardiac output in. However, its chronic activation becomes maladaptive and promotes heart failure progression, making necessary the administration of RAAS blockers drugs, like the ACE-inhibitors. In human beings, and more recently in dogs, a drugs’ effectiveness decrease and a concurrent aldosterone increase have been evidenced. This is known as aldosterone breakthrough. The Authors propose a review of the literature.