On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Academic Article

Publication Date:

2018

Citation:

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin / L. Medve, S. Achilli, S. Serna, F. Zuccotto, N. Varga, M. Thepaut, M. Civera, C. Vives, F. Fieschi, N. Reichardt, A. Bernardi. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 24:54(2018 Sep 25), pp. 14448-14460. [10.1002/chem.201802577]

abstract:

A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed to probe their selectivity against other CLRs.

IRIS type:

01 - Articolo su periodico

Keywords:

carbohydrates , C-type lectins, drug discovery, glycomimetics, microarrays

List of contributors: