Publication Date:
2010
Citation:
Curcumin derivatives as new ligands of Aβ peptides / C. Airoldi, C. Zona, E. Sironi, L. Colombo, M. Messa, D. Aurilia, M. Gregori, M. Masserini, M. Salmona, F. Nicotra, B. La Ferla. - In: JOURNAL OF BIOTECHNOLOGY. - ISSN 0168-1656. - 156:4(2010), pp. 317-324.
abstract:
Curcumin derivatives with high chemical stability, improved solubility and carrying a functionalized appendage for the linkage to other entities, have been synthesized in a straightforward manner. All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits. © 2011 Elsevier B.V..
IRIS type:
01 - Articolo su periodico
Keywords:
Aβ ligands; Aβ peptides; Alzheimer's disease; Brain amyloid plaque staining; Conformational analysis; Curcumin derivatives; NMR interaction studies; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain Chemistry; Curcumin; Histocytochemistry; Humans; Mice; Mice, Transgenic; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Protein Binding; Solubility; Biotechnology; Applied Microbiology and Biotechnology
List of contributors:
C. Airoldi, C. Zona, E. Sironi, L. Colombo, M. Messa, D. Aurilia, M. Gregori, M. Masserini, M. Salmona, F. Nicotra, B. La Ferla
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