Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R

Academic Article

Publication Date:

2021

Citation:

Ex vivo microRNA and gene expression profiling of human Tr1-like cells suggests a role for miR-92a and -125a in the regulation of EOMES and IL-10R / M. De Simone, M. Chirichella, S. Emming, S. Mazzara, V. Ranzani, P. Gruarin, G. Moschetti, N. Pulvirenti, S. Maglie, C. Vasco, M.C. Crosti, G. Rossetti, M. Pagani, S. Abrignani, S. Monticelli, J. Geginat. - In: EUROPEAN JOURNAL OF IMMUNOLOGY. - ISSN 0014-2980. - 51:12(2021 Dec), pp. 3243-3246. [10.1002/eji.202149315]

abstract:

Ex vivo gene expression and miRNA profiling of Eomes+ Tr1-like cells suggested that they represent a differentiation stage that is intermediate between Th1-cells and cytotoxic CD4+ T-cells. Several microRNAs were downregulated in Eomes+ Tr1-like cells that might inhibit Tr1-cell differentiation. In particular, miR-92a targeted Eomes, while miR-125a inhibited IFN-g and IL-10R expression.

IRIS type:

01 - Articolo su periodico

Keywords:

EOMES; IL-10R; microRNAs; Tr1-like cells

List of contributors: