Raffaella Molteni
Department of Medical Biotechnology and Translational Medicine (BioMeTra)
Via Vanvitelli 9, 20129, Milan
+39-02-50317010/007

ORCID ID: 0000-0002-5481-7572
SCOPUS ID: 7003888920
RESEARCH ID: Q-5011-2017


POSITION

Full Professor of Pharmacology
Head of Bachelor's Programme in Medical Biotechnologies

WORK EXPERIENCE

From November 2020
Full Professor of Pharmacology
Medical Biotechnology and Translational Medicine Dept., University of Milan
 Pharmacology teacher in bachelors, masters and postgraduate programme courses of the Faculty of Medicine
 Head of the Psychoimmunopharmacology and stress-related disorders laboratory
 Faculty member of the “Experimental Medicine” doctoral programme
 Mentor in the Virgilio program

From-October 2016
Head, Laboratory of Psycoimmunopharmacology and Stress-related Disorders
Medical Biotechnology and Translational Medicine Dept., University of Milan

The experimental activity is the field of neuropsychopharmacology, with research primarily oriented to the identification and characterization of molecular mechanisms altered in psychiatric disorders that might represent potential targets for pharmacological treatment aimed at restoring normal brain function. In particular, given the role of stress as crucial environmental risk factor for psychiatric diseases, one of the main goal of the research activity is to study the impact of acute and chronic stress in order to better understand the molecular basis of individual stress vulnerability and resilience. Moreover, the lab is specifically interested to the role of neuroinflammation in the etiology of psychiatric disorders and in the mechanism of action of psychotropic drug.

October 2016-October 2020
Associate Professor of Pharmacology
Medical Biotechnology and Translational Medicine Dept., University of Milan

October 2010-September 2016
Assistant Professor of Pharmacology
Pharmacological and Biomolecular Sciences Dept., University of Milan

January 2003-September 2010
Research Assistant
Pharmacological Sciences Dept., University of Milan

June 2000-December 2002
Postdoctoral Fellow
University of California at Los Angeles (UCLA), Los Angeles, CA, USA
Dept. of Neurosurgery and Dept. of Physiological Science, Brain Injury Research Center
Laboratory of Prof. Fernando Gómez-Pinilla

July 1998-December 1998
Research Fellow
National Institute of Health (NIH), Bethesda, MD, USA
National Institute of Mental Health (NIMH), Clinical Brain Disorders Branch
Laboratory of Drs. Barbara K. Lipska and Daniel R. Weinberger

September 1994-May 2000
Research Associate
Institute of Pharmacological Sciences Dept., Center for Neuropharmacology, University of Milan



EDUCATION AND TRAINING

2000 PhD in “Biotechnology applied to pharmacology”
University of Milan

1996 Specialization in Pharmacology
University of Milan

1994 Master’s degree in Pharmaceutical Chemistry and Technology
University of Milan

PERSONAL SKILLS

Mother tongue(s) Italian

Other language(s) UNDERSTANDING SPEAKING WRITING
Listening Reading Spoken interaction Spoken production
English C1 C1 C1 C1 C1
Levels: A1/A2: Basic user - B1/B2: Independent user - C1/C2 Proficient user
Common European Framework of Reference for Languages



Communication and Organisational / managerial skills
Good communication skills acquired over years by teaching in University classes and presenting data in national and international conferences.
Good organisational skills acquired in training and supervision of ungraduated and PhD students as well as in organizing and coordinating research teams.


ADDITIONAL INFORMATION

Publications
Author of 76 article on peer review journals
Total Impact Factor: 371,934
Average Impact Factor: 4,894
Total Citations (Scopus) 5866
H-index (Scopus) 40


Congress/Seminar
Speaker and invited speaker at national and international congresses as well as at Italian and foreign research institutions.


Projects/Grants
Recipient of grants from Italian Agencies (Ministry of University), non-profit organizations (FISM-AISM), and pharmaceutical industries.


Membership
• Italian Society of Pharmacology (SIF): member and secretary of the”Neuropsychopharmacology” working group
• Italian Society of Neuropsychopharmacology (SINPF): member
• Italian Society for Neuroecsience (SINS): member
• Neuro-Nest - Neuroscience Network at Statale (Università degli Studi di Milano): member
• American Society for Neuroscience (SFN): member
.




ANNEXES

Publication list

Personal information I authorize the handling of personal information in this curriculum, according to D.Lgs n. 196/03 and following modifications and Regulations EU 679/2016 (General Regulations concerning Data Protection or GRDP) and art. 7 of University Regulations concerning protection of personal information.

I authorize, according to D.lgs 14/03/2013 n. 33 concerning transparency, in case of conferment of the position and of the fellowship, the publication of this curriculum in the web site of Università degli Studi di Milano in the section “Amministrazione trasparente”, “Consulenti e collaboratori”.


December 15th, 2020


N. Autori e dettagli
1 Riva M.A., Tascedda F., Molteni R. and Racagni G.
Regulation of NMDA receptor subunit mRNA expression in the rat brain during postnatal development.
Molecular Brain Research 25: 209-216 (1994).
ISSN: 0169-328X

2 Tascedda F., Molteni R., Racagni G. and Riva M.A.
Acute and chronic changes in K+-induced depolarization alter NMDA and nNOS gene expression in cultured cerebellar granule cells.
Molecular Brain Research 40: 171-174 (1996).
ISSN: 0169-328X

3 Riva M.A., Molteni R., Lovati E., Fumagalli F. and Racagni G.
Cyclic AMP-dependent regulation of fibroblast growth factor-2 messenger RNA levels in rat cortical astrocytes: comparison with fibroblast growth factor-1 and ciliary neurotrophic factor.
Molecular Pharmacology 49: 699-706 (1996).
ISSN: 0026-895X

4 Riva M.A., Molteni R. and Racagni G.
L-deprenyl potentiates cAMP-induced elevation of FGF-2 mRNA levels in rat cortical astrocytes.
NeuroReport 8: 2165-2168 (1997).
ISSN: 0959-4965
Q1 (Neuroscience, riferito al 1999)

5 Simonato M., Molteni R., Bregola G., Muzzolini A., Piffanelli M., Beani L., Racagni G. and Riva M.
Different patterns of induction of FGF-2, FGF-1 and BDNF mRNAs during kindling epileptogenesis in the rat.
European Journal of Neuroscience 10: 955-963 (1998).
ISSN: 0953-816X


6 Riva M.A., Molteni R. and Racagni G.
Differential regulation of FGF-2 and FGFR-1 in rat cortical astrocytes by dexamethasone and isoproterenol.
Molecular Brain Research 57: 38-45 (1998).
ISSN: 0169-328X

7 Maggio R., Riva M., Vaglini F., Fornai F., Molteni R., Armogida M., Racagni G. and Corsini G.U.
Nicotine prevents experimental parkinsonism in rodents and induces striatal increase of neurotrophic factors.
Journal of Neurochemistry 71: 2439-2446 (1998).
ISSN: 0022-3042

8 Riva M.A., Molteni R., Tascedda F., Massironi A. and Racagni G.
Selective modulation of fibroblast growth factor-2 expression in the rat brain by atypical antipsychotic clozapine.
Neuropharmacology 38: 1075-1082 (1999).
ISSN: 0028-3908

9 Roceri M., Molteni R., Racagni G. and Riva M.A.
Calcium-dependent modulation of FGF-2 expression in cultured cerebellar granule neurons.
NeuroReport 11: 3615-9 (2000).
ISSN: 0959-496

10 Roceri M., Molteni R., Fumagalli F., Racagni G., Corsini G.U., Maggio R. and Riva M.A.
Stimulatory role of dopamine on FGF-2 expression in rat striatum.
Journal of Neurochemistry 76: 990-997 (2001).
ISSN: 0022-3042

11 Molteni R., Lipska B.K., Weinberger D.R., Racagni G. and Riva M.A.
Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia.
Molecular Psychiatry 6: 285-292 (2001).
ISSN: 1359-4184

12 Meroni P.L., Raschi E., Testoni C., Tincani A., Balestrieri G., Molteni R., Khamashta M.A., Tremoli E. and Camera M.
Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype.
Arthritis & Rheumatism 44(12): 2870-2878 (2001).
ISSN: 0004-3591 (ora Arthritis & Rheumatology)

13 Molteni R., Fumagalli F., Magnaghi V., Roceri M., Gennarelli M., Racagni G., Melcangi R.C. and Riva M.A.
Modulation of fibroblast growth factor-2 by stress and corticosteroids: from developmental events to adult brain plasticity.
Brain Research Reviews 37(1-3): 249-258 (2001).
ISSN: 0165-0173

14 Griesbach G.S., Hovda D.A., Molteni R. and Gómez-Pinilla F.
Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity.
Journal of Neurotrauma 19(7): 803-814 (2002).
ISSN: 0897-7151

15 Molteni R., Barnard R.J., Ying Z., Roberts C.K. and Gómez-Pinilla F.
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning.
Neuroscience 112(4): 803-814 (2002).
ISSN: 0306-4522

16 Gómez-Pinilla F., Ying Z., Roy R.R., Molteni R. and Edgerton V.E.
Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity.
Journal of Neurophysiology 88(5): 2187-2195 (2002).
ISSN: 0022-3077

17 Molteni R., Ying Z. and Gómez-Pinilla F.
Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray.
European Journal of Neuroscience 16(6): 1107-1116 (2002).
ISSN: 0953-816X

18 Fumagalli F., Molteni R., Roceri M., Bedogni F., Santero R., Fossati C., Gennarelli M., Racagni G. and Riva M.A.
Effect of antipsychotic drugs on brain-derived neurotrophic factor expression under reduced N-methyl-D-aspartate receptor activity.
Journal of Neuroscience Research 72(5): 622-628 (2003).
ISSN: 0360-4012

19 Wu A., Molteni R., Ying Z. and Gómez-Pinilla F.
A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor.
Neuroscience 119(2): 365-375 (2003).
ISSN. 0306-4522


20 Molteni R., Wu A., Vaynman S., Ying Z., Barnard R.J. and Gomez-Pinilla F.
Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor.
Neuroscience 123(2): 429-440 (2004).
ISSN: 0306-4522

21 Griesbach G.S., Hovda D.A., Molteni R., Wu A. and Gomez-Pinilla F.
Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function.
Neuroscience 125(1): 129-139 (2004).
ISSN: 0306-4522

22 Molteni R., Zheng JQ., Ying Z., Gomez-Pinilla F. and Twiss J.L.
Voluntary exercise increases axonal regeneration from sensory neurons.
Proc Natl Acad Sci USA 101(22): 8473-8478 (2004).
ISSN: 0027-8424

23 Fumagalli F., Molteni R., Bedogni F., Gennarelli M., Perez J., Racagni G. and Riva M.A.
Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801.
NeuroReport 15(13): 2109-2112 (2004).
ISSN: 0959-4965

24 Riva M.A., Molteni R., Bedogni F., Racagni G. and Fumagalli F.
Emerging role of the FGF system in psychiatric disorders.
Trends in Pharmacological Sciences 26(5): 228-231 (2005).
ISSN: 0165-6147

25 *Fumagalli F., *Molteni R., Calabrese F., Frasca A., Racagni G. and Riva M.A.
Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1/2 phosphorylation in rat brain.
Journal of Neurochemistry 93(6): 1551-1560 (2005).
ISSN: 0022-3042

26 Molteni R., Calabrese F., Bedogni F., Tongiorgi E., Fumagalli F. Racagni G. and Riva M.A.
Chronic treatment with fluoxetine up-regulates cellular BDNF mRNA expression in rat dopaminergic regions.
International Journal of Neuropsychopharmacology 9(3): 307-317 (2006).
ISSN: 1461-1457

27 Fumagalli F. Molteni R., Racagni G. and Riva M.A.
Stress during development: impact on neuroplasticity and relevance to psychopathology.
Progress in Neurobiology 81(4): 197-217 (2007).
ISSN: 0301-0082

28 Calabrese F., Molteni R., Maj P.F., Cattaneo A., Gennarelli M., Racagni G. and Riva M.A.
Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein.
Neuropsychopharmacology 32(11): 2351-2359 (2007).
ISSN: 0893-133X

29 Molteni R., Pasini M., Moraschi S., Gennarelli M., Drago F., Racagni G. and Riva M.A.
Reduced activation of intracellular signaling pathways in rat prefrontal cortex after chronic phencyclidine administration.
Pharmacological Research 57(4): 296-302 (2008).
ISSN: 1043-6618

30 Fumagalli F., Molteni R., Calabrese F., Maj P.F, Racagni G. and Riva M.A.
Neurotrophic factors in neurodegenerative disorders: potential for therapy.
CNS Drugs 22(12): 1005-1019 (2008).
ISSN: 1172-7047

31 Molteni R., Calabrese F., Mancini M., Racagni G. and Riva M.A.
Basal and stress-induced modulation of activity-regulated cytoskeletal associated protein (Arc) in the rat brain following duloxetine treatment.
Psychopharmacology 201(2): 285-292 (2008).
ISSN: 0033-3158

32 Molteni R., Calabrese F., Cattaneo A., Mancini M., Gennarelli M., Racagni G. and Riva M.A.
Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine.
Neuropsychopharmacology 34(6): 1523-1532 (2009).
ISSN: 0893-133X

33 *Molteni R., *Calabrese F., Racagni G., Fumagalli F. and Riva M.A.
Antipsychotic drug actions on gene modulation and signaling mechanisms.
Pharmacology and Therapeutics 124(1): 74-85 (2009).
ISSN: 0163-7258 0163

34 Molteni R., Calabrese F., Maj P.F., Olivier J.D.A., Racagni G., Ellenbroek B.A. and Riva M.A.
Altered expression and modulation of activity-regulated cytoskeletal associated protein (Arc) in serotonin transporter knockout rats.
European Neuropsychopharmacology 19(12): 898-904 (2009).
ISSN: 0924-977X

35 Calabrese F., Molteni R., Racagni G. and Riva M.A.
Neuronal plasticity: a link between stress and mood disorders.
Psychoneuroendocrinology 34(Suppl. 1): S208-S216 (2009).
ISSN: 0306-4530

36 Molteni R., Cattaneo A., Calabrese F., Macchi F., Olivier J.D.A., Racagni G., Ellenbroek B.A., Gennarelli M. and Riva M.A.
Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans.
Neurobiology of Disease 37(3): 747-755 (2010).
ISSN: 0969-9961

37 Molteni R., Calabrese F., Pisoni S., Gabriel C., Mocaer E., Racagni G. and Riva M.A.
Synergistic mechanisms in the modulation of the neurotrophin BDNF in the rat prefrontal cortex following acute agomelatine administration.
World Journal of Biological Psychiatry 11(2): 148-153 (2010).
ISSN: 1562-2975

38 Molteni R., Calabrese F., Chourbaji S., Brandwein C., Racagni G., Gass P. and Riva M.A.
Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activity-regulated cytoskeleton associated protein.
Journal of Psychopharmacology 24(4): 595-603 (2010).
ISSN: 0269-8811

39 Calabrese F., Molteni R., Cattaneo A., Macchi F., Racagni G., Gennarelli M., Ellenbroek B.A. and Riva M.A.
Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms.
Molecular Pharmacology 77(5): 846-853 (2010).
ISSN: 0026-895X

40 Bocchio-Chiavetto L., Bagnardi V., Zanardini R., Molteni R., Nielsen M.G., Placentino A., Giovannini C., Rillosi L., Ventriglia M., Riva M.A. and Gennarelli M.
Serum and plasma BDNF levels in major depression: a replication study and meta-analyses.
World Journal of Biological Psychiatry 11(6): 763-773 (2010).
ISSN: 1562-2975

41 Calabrese F., Molteni R., Gabriel C., Mocaer E., Racagni G. and Riva M.A.
Modulation of neuroplastic molecules in selected brain regions after chronic administration of the novel antidepressant agomelatine.
Psychopharmacology 215(2): 267-275 (2011).
ISSN: 0033-3158

42 Calabrese F., Molteni R. and Riva M.A.
Antistress properties of antidepressant drugs and their clinical implications.
Pharmacology and Therapeutics 132(1): 39-56 (2011).
ISSN: 0163-7258

43 Racagni G., Riva M.A., Molteni R., Musazzi M., Calabrese F., Popoli M. and Tardito D.
Mode of action of agomelatine: synergy between melatonergic and 5-HT2C receptors.
World Journal of Biological Psychiatry 12(8): 574-87 (2011).
ISSN: 1562-2975

44 Ruggeri M. et al.
A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial.
Trials 13:73 (2012).
ISSN: 1745-6215

45 Calabrese F., Guidotti G., Molteni R., Racagni G., Mancini M. and Riva M.A.
Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment.
PLoS ONE 7(5): e37916 (2012).
ISSN: 1932-6203

46 Tardito D., Molteni R., Popoli M. and Racagni G.
Synergistic mechanisms involved in the antidepressant effects of agomelatine.
European Neuropsychopharmacology 22 Suppl 3: S482-486. (2012).
ISSN: 0924-977X

47 Chourbaji S., Hortnagl H., Molteni R., Riva M.A., Gass P. and Hellweg R.
The impact of environmental enrichment on sex-specific neurochemical circuitries - Effects on brain-derived neurotrophic factor and the serotonergic system.
Neuroscience 220:267-76 (2012).
ISSN: 0306-4522

48 Anacker C., Cattaneo A., Musaelyan K., Zunszain P.A., Horowitz M., Molteni R., Luoni A., Calabrese F., Tansey K., Gennarelli M., Thuret S., Price J., Uher F., Riva M.A. and Pariante C.M.
Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis.
Proc Natl Acad Sci USA 110(21): 8708-13 (2013).
ISSN: 0027-8424

49 Macchi F, Homberg J.R., Calabrese F., Zecchillo C., Racagni G., Riva M.A., Molteni R.
Altered inflammatory responsiveness in serotonin transporter mutant rats.
Journal of Neuroinflammation 10: 116 (2013).
ISSN: 1742-2094

50 Molteni R., Macchi F. and Riva M.A.
Gene expression profiling as functional readout of rodent models for psychiatric disorders.
Cell and Tissue Research, 354(1): 51-60 (2013).
ISSN: 0302-766X

51 Molteni R., Macchi F., Zecchillo C., Dell'Agli M., Colombo E., Calabrese F., Guidotti G., Racagni G. and Riva M.A.
Modulation of the inflammatory response in rats chronically treated with the antidepressant agomelatine.
European Neuropsychopharmacology. 23(11): 1645-1655 (2013).
ISSN: 0924-977X

52 Capannolo M., Ciccarelli C., Molteni R., Fumagalli F., Rocchi C., Romeo S., Fasciani I., Aloisi G., Zani B.M., Riva M.A. and Maggio R.
Nitric oxide synthase inhibition reverts muscarinic receptor down-regulation induced by pilocarpine- and kainic acid-evoked seizures in rat fronto-parietal cortex.
Epilepsy Research 108(1): 11-19 (2014).
ISSN: 0920-1211

53 Homberg J.R., Molteni R., Calabrese F. and Riva M.A.
The serotonin-BDNF duo: developmental implications for the vulnerability to psychopathology.
Neuroscience and Biobehavioral Reviews 43:35-47 (2014). ISSN: 0149-7634

54 Calabrese F., Rossetti A.C., Racagni G., Gass P., Riva M.A. and Molteni R.
Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity.
Frontiers in Cellular Neuroscience 8: 430 (2014).
ISSN: 1662-5102

55 Luoni A., Richetto J., Racagni G. and Molteni R.
The long-term impact of early adversities on psychiatric disorders: focus on neuronal plasticity.
Current Pharmaceutical Design 21(11): 1388-1395 (2015).
ISSN: 1381-6128

56 Luoni A., Macchi F., Papp M., Molteni R. and Riva M.A.
Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex.
International Journal of Neuropsychopharmacology 18(4): 1-12 (2014).
ISSN: 1461-1457

57 Pase C.S., Teixeira A.M., Roversi K., Dias V.T., Calabrese F., Molteni R., Franchi S., Panerai A.E., Riva M.A. and Burger M.E.
Olive oil-enriched diet reduces brain oxidative damages and ameliorates neurotrophic factor gene expression in different life stages of rats.
Journal of Nutritional Biochemistry 26: 1200-1207 (2015).
ISSN: 0955-2863

58 Rossetti A.C., Papp M., Gruca P., Paladini M.S., Racagni G., Riva M.A. and Molteni R.
Stress-induced anhedonia is associated with the activation of the inflammatory system in the rat brain: restorative effect of pharmacological intervention.
Pharmacological Research 103: 1-12 (2016).
ISSN: 1043-6618

59 Molteni R., Rossetti A.C., Savino E., Racagni G. and Calabrese F.
Chronic mild stress modulates activity-dependent transcription of BDNF in rat hippocampal slices.
Neural Plasticity Vol. 2016, Article ID 2592319 (2016).
ISSN: 2090-5904

60 Calabrese F., Savino E., Papp M., Molteni R. and Riva M.A.
Chronic mild stress-induced alterations of clock gene expression in rat prefrontal cortex: modulatory effects of prolonged lurasidone treatment.
Pharmacological Research 104: 140-150 (2016).
ISSN: 1043-6618

61 Calabrese F., Riva M.A. and Molteni R.
Synaptic alterations associated with depression and schizophrenia: potential as a therapeutic target.
Expert Opinion on Therapeutic Targets 20(10):1195-1207 (2016).
ISSN: 1472-8222
Q1 (Molecular Medicine)
Q1 (Pharmacology)

62 Rossetti A.C., Paladini M.S, Colombo M., Gruca P., Lason-Tyburkiewicz M., Tota-Glowczyk K., Papp M., Riva M.A. and Molteni R.
Chronic stress exposure reduces parvalbumin expression in the rat hippocampus through an imbalance of redox mechanisms: restorative effect of the antipsychotic lurasidone.
International Journal of Neuropsychopharmacology 21(9): 883-893 (2018)
ISSN: 1461-1457

63 Manfré G., Novati A., Faccini I., Rossetti A.C., Bosch K., Molteni R., Riva M.A., Van der Harst J.E., Nguyen H.P. and Homberg J.R.
BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates.
PLoS ONE. 13(2):e0192289 (2018)
ISSN: 1932-6203

64 Caraci F., Calabrese F., Molteni R., Bartova L., Dold M., Leggio G.M., Fabbri C., Mendlewicz J., Racagni G., Kasper S., Riva M.A. and Drago F.
International union of basic and clinical pharmacology CIV: the neurobiology of treatment-resistant depression: from antidepressant classifications to novel pharmacological targets.
Pharmacological Reviews 70(3):475-504 (2018).
ISSN: 0031-6997

65 Rossetti A.C., Paladini M.S., Racagni G., Riva M.A., Cattaneo A. and Molteni R.
Genome-wide analysis of LPS-induced inflammatory response in the rat ventral hippocampus: modulatory activity of the antidepressant agomelatine.
World J Biological Psychiatry. 19(5):390-401 (2018)
Epub 2017 Mar 24.
ISSN: 2090-5904

66 Morroni F., Sita G., Graziosi A., Ravegnini G., Molteni R., Paladini M.S., Dias K.S.T., Dos Santos A.F., Viegas C. Jr, Camps I., Pruccoli L., Tarozzi A. and Hrelia P.
PQM130, a novel feruloyl-donepezil hybrid compound, effectively ameliorates the cognitive impairments and pathology in a mouse model of Alzheimer's disease.
Frontiers in Pharmacology (2019) 10:658.
ISSN 1663-9812
Q1 (Pharmacology)

67 Brivio P., Paladini M.S., Racagni G., Riva M.A., Calabrese F. and Molteni R.
From healthy aging to frailty: in search of the underlying mechanisms.
Current Medicinal Chemistry (2019) 26(20):3685-3701.
ISSN: 0929-8673

68 Rossetti A.C., Paladini M.S., Trepci A., Mallien A., Riva M.A., Gass P. and Molteni R.
Differential neuroinflammatory response in male and female mice: a role for BDNF.
Frontiers in Molecular Neuroscience 12:166 (2019)
ISSN: 1662-5099

69 Moschetti G., Amodeo G., Paladini M.S., Molteni R., Balboni G., Panerai A., Sacerdote P. and Franchi S.
Prokineticin 2 promotes and sustains neuroinflammation in vincristine treated mice: focus on pain and emotional like behavior.
Brain, Behavior and Immunity 82:422-431 (2019).
ISSN: 0889-1591

70 Rossetti A.C., Paladini M.S., Riva M.A. and Molteni R.
Oxidation-reduction mechanisms in psychiatric disorders: a novel target for pharmacological intervention.
Pharmacology and Therapeutics 210, 107520 (2020)
ISSN: 0163-7258 0163

71 Marchisella F., Paladini M.S., Guidi A., Begni V., Brivio P., Spero V., Calabrese F., Molteni R. and Riva M.A.
Chronic treatment with the antipsychotic drug blonanserin modulates the responsiveness to acute stress with anatomical selectivity.
Psychopharmacology 237(6):1783–1793 (2020).
ISSN: 0033-3158

72 Hrelia P., Sita G., Ziche M., Ristori E., Marino A., Cordaro M., Molteni R., Spero V., Malaguti M., Morroni F. and Hrelia S.
Common protective strategies in neurodegenerative disease: focusing on risk factors to target the cellular redox system.
Oxid Med Cell Longev. 2020:8363245 (2020)

73 Brivio P., Sbrini G., Corsini G., Paladini MS., Racagni G., Molteni R. and Calabrese F.
Chronic restraint stress inhibits the response to a second hit in adult male rats: a role for BDNF signaling.
Int J Mol Sci. 21(17):6261 (2020).

74 Paladini M.S., Marangon D., Rossetti A.C., Guidi A., Coppolino G.T., Negri C., Spero V., Abbracchio M.P., Lecca D. and Molteni R.
Prenatal stress impairs spinal cord oligodendrocyte maturation via BDNF signaling in the experimental autoimmune encephalomyelitis model of multiple sclerosis.
Cell Mol Neurobiol. (2020). doi: 10.1007/s10571-020-01014-x. Online ahead of print

75 Paladini M.S., Spero V., Begni V., Marchisella F., Guidi A., Gruca P., Lason M., Litwa E., Papp M., Riva M.A. and Molteni R.
Behavioral and molecular effects of the antipsychotic drug blonanserin in the chronic mild stress model.
Pharmacol Res. (2020) 163:105330. doi: 10.1016/j.phrs.2020.105330. Online ahead of print.
ISSN: 0031-6997

76 Perrotta C., Cattaneo M.G., Molteni R. and De Palma C.
Autophagy in the regulation of tissue differentiation and homeostasis.
Front Cell Dev Biol. (2020) 8:602901. doi: 10.3389/fcell.2020.602901. eCollection 2020