Data di Pubblicazione:
2015
Citazione:
Myeloid cells in cancer-related inflammation / N. Caronni, B. Savino, R. Bonecchi. - In: IMMUNOBIOLOGY. - ISSN 0171-2985. - 220:2(2015 Feb), pp. 249-253. [10.1016/j.imbio.2014.10.001]
Abstract:
Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cancer-related inflammation; Chemokine; Myeloid cells; Myeloid-derived suppressor cells; Tumor-associated macrophages; Tumor-associated neutrophils; Animals; Bone Marrow; Cell Movement; Humans; Inflammation; Myeloid Cells; Neoplasm Metastasis; Neoplasms; Tumor Microenvironment
Elenco autori:
N. Caronni, B. Savino, R. Bonecchi
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