Data di Pubblicazione:
2009
Citazione:
Protein folding : can high-performance computing improve our understanding? / G. Tiana. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - 32:2(2009), pp. 9-12.
Abstract:
Proteins are complex physical systems of great biological and pharmaceutical
interest. Computer simulations can be useful to understand how they
fold to their biologically active conformation, but have to face two problems, namely
the roughness of the energy landscape and the wide range of time scales associated
with the folding process. Models at atomic detail are able to describe the protein
with a high degree of realism, but are computationally very demanding and their
results usually are difficult to analyse. Models with simplified degrees of freedom
are less accurate but are good at highlighting the basic physical mechanism which
controls protein dynamics. A combination of the two can be the right solution to
the protein folding problem.
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Tiana
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