Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: A Telescoped Approach
Articolo
Data di Pubblicazione:
2021
Citazione:
Continuous Flow Synthesis of α-Trifluoromethylthiolated Esters and Amides from Carboxylic Acids: A Telescoped Approach / F. Franco, S. Meninno, A. Lattanzi, A. Puglisi, M. Benaglia. - In: JOURNAL OF ORGANIC CHEMISTRY. - ISSN 0022-3263. - 86:20(2021 Oct 15), pp. 14207-14212. [10.1021/acs.joc.1c01270]
Abstract:
A continuous flow approach to access α-trifluoromethylthiolated esters and amides using commercially available arylacetic acids and N-(trifluoromethylthio)phthalimide as the electrophilic reagent is described. The experimental protocol involves the in-flow conversion of the carboxylic acid into N-acylpyrazole followed by the α-trifluoromethylthiolation in a PTFE coil reactor and final reaction with primary or secondary amines, or alcohols, to afford in a telescoped process α-substituted SCF3 amides and esters, respectively, in good overall yield and short reaction times.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alcohols; Esters; Indicators and Reagents; Amides; Carboxylic Acids;
Elenco autori:
F. Franco, S. Meninno, A. Lattanzi, A. Puglisi, M. Benaglia
Link alla scheda completa:
Link al Full Text: