Data di Pubblicazione:
2021
Citazione:
Enantio- and Regioselective Palladium(II)-Catalyzed Dioxygenation of (Aza)-Alkenols / E.M. Beccalli, S. Giofrè, L. Molteni, D. Nava, L. Lo Presti. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - 60:40(2021 Sep 27), pp. 21723-21727. [10.1002/anie.202109312]
Abstract:
An oxidative Pd-catalyzed intra-intermolecular dioxygenation of (aza)-alkenols has been reported, with total regioselectivity. To study the stereoselectivity, different chiral ligands as well as different hypervalent iodines have been compared. In particular, by using C-6 modified pyridinyl-oxazoline (Pyox) ligand and hypervalent iodine bearing an aromatic ring, an excellent enantio- and diastereoselectivity has been achieved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
alkene difunctionalizations; alkenols; dioxygenation; enantioselectivity; hypervalent iodine; Pd catalysis
Elenco autori:
E.M. Beccalli, S. Giofrè, L. Molteni, D. Nava, L. Lo Presti
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