NF1 Gene Mutation Mediates Neuronal Signaling De-Regulation Triggering Pediatric Optic Glioma Development: Another Small Step towards a Cure of NF1 Disorder?
Articolo
Data di Pubblicazione:
2021
Citazione:
NF1 Gene Mutation Mediates Neuronal Signaling De-Regulation Triggering Pediatric Optic Glioma Development: Another Small Step towards a Cure of NF1 Disorder? / P. Riva, V. Tritto. - In: EC NEUROLOGY. - 13:9(2021 Aug 12), pp. 11-12.
Abstract:
Pediatric optic pathway gliomas (OPGs) account for 20% of brain tumors [1].
These tumors are characterized by a low-grade growth and in some cases can be associated with a tumor predisposition syndrome. In particular, 15% of patients with neurofibromatosis type 1 (NF1) develop OPGs [2].
Sporadic and NF1-associated OPGs show different outcomes and are characterized by different radiological features [3], nevertheless both forms show activation of the MAPK (mitogen-activated protein kinase) and mTOR pathways.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
NF1, Optic glioma, Therapy
Elenco autori:
P. Riva, V. Tritto
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