Clinical Value of Tissue Transglutaminase Antibodies in Celiac Patients over a Long Term Follow-Up
Articolo
Data di Pubblicazione:
2021
Citazione:
Clinical Value of Tissue Transglutaminase Antibodies in Celiac Patients over a Long Term Follow-Up / E. Farina, L. Roncoroni, V. Lombardo, A. Scricciolo, M. Vecchi, L. Doneda, L. Elli. - In: NUTRIENTS. - ISSN 2072-6643. - 13:9(2021 Aug 31), pp. 3057.1-3057.9. [10.3390/nu13093057]
Abstract:
Introduction & Aim: Anti-tissue transglutaminase antibody (tTGA) titer is used during the
follow-up of celiac patients to evaluate gluten-free diet (GFD) responsiveness. However, no clear
data are available on this issue. The aim of this study was to evaluate tTGA significance during
celiac disease (CD) monitoring. Methods: From January 2017 to January 2020, consecutive CD
patients on a GFD with persistent positive tTGA were enrolled. Antibody titres were evaluated on
a yearly basis from CD diagnosis to the last follow-up. Urinary gluten detection tests, duodenal
histology and capsule enteroscopy (CE) were performed. A tTGA-positive cohort was compared
with a control group composed of 212 treated CD patients with negative tTGA. Results: 65 patients
(12% males, median age at enrollment and CD diagnosis, 37 (14–86) and 31 (1–76), respectively,
median follow up 4 (1–26) years) presented with positive tTGA during follow-up. Overall, the tTGA
titres were 3 (1–79) fold increased (ULN). Three different tTGA trends were recognized: (I) 36 (55%)
patients with a progressive titresdecrease; (II) 16 (25%) patients with a fluctuating behavior; (III) 13
(20%) patients with a steady state or increased titres. tTGA+ patients did not present with different
clinical and demographic parameters. Duodenal atrophy was present in 10% vs. 36% of the tTGA
positive vs. negative group (p < 0.005), respectively. Gluten detection results were positive in 3 (8%)
cases, all in the III group. In tTGA+ patients, CE did not identify any CD-related complications.
Conclusions: tTGA positivity during CD follow up did not present a relevant clinical significance
without association with autoimmune comorbidities and mucosal damage.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
celiac disease; anti-tissue transglutaminase; urinary gluten detect;
Elenco autori:
E. Farina, L. Roncoroni, V. Lombardo, A. Scricciolo, M. Vecchi, L. Doneda, L. Elli
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