Printing of cutaneous patches loaded with propranolol for the treatment of infantile haemangiomas
Articolo
Data di Pubblicazione:
2021
Citazione:
Printing of cutaneous patches loaded with propranolol for the treatment of infantile haemangiomas / U.M. Musazzi, C.G.M. Gennari, S. Franzè, P. Minghetti, F. Cilurzo. - In: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. - ISSN 1773-2247. - 66(2021 Dec), pp. 102767.1-102767.6. [10.1016/j.jddst.2021.102767]
Abstract:
Topical propranolol has been used in clinics for treating cutaneous infantile haemangiomas, but frequent applications of semi-solid preparations are required to maintain therapeutic drug concentrations in the skin layers over time. This work aims to study the preparation of cutaneous propranolol patches by hot-melt ram extrusion printing, a novel technique suitable for the personalization of the dosage forms. The preparation steps are: i) mixing of a poly-ammonium methacrylate polymer (Eudragit RL) with a suitable amount of plasticizer [acetyl triethyl citrate (ATEC), triacetin or tributyl citrate, TBC] and the drug (propranolol base, or hydrochloride), ii) the melting in the ram extruder, and iii) the printing on the backing layer foil. All formulations released the loaded drug in a reasonable time and exhibited suitable adhesive properties. The determination of permeation profiles of the drug revealed the patch made of Eudragit RL and TBC and containing 1% propranolol hydrochloride as the most promising formulation for ensuring the drug retention on the human epidermis (Qret/J = 1.32) and, therefore, it can be selected when a superficial haemangioma has to be treated. Conversely, the patch made of Eudragit RL and ATEC and 1% propranolol base can be used in the case of deep haemangiomas.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cutaneous patch; Eudragit RL; Hot-melt extrusion; Infantile haemangiomas; Printing; Propranolol
Elenco autori:
U.M. Musazzi, C.G.M. Gennari, S. Franzè, P. Minghetti, F. Cilurzo
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