Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study
Articolo
Data di Pubblicazione:
2021
Citazione:
Clinical Evolution and Quality of Life in Clinically Based COPD Chronic Bronchitic and Emphysematous Phenotypes: Results from the 1-Year Follow-Up of the STORICO Italian Observational Study / F. Blasi, R. Antonelli Incalzi, G.W. Canonica, P. Schino, G. Cuttitta, A. Zullo, A. Ori, N. Scichilone. - In: INTERNATIONAL JOURNAL OF COPD. - ISSN 1178-2005. - 16:(2021), pp. 2133-2148. [10.2147/COPD.S310428]
Abstract:
Introduction: Understanding clinical evolution of chronic obstructive pulmonary disease
(COPD) is crucial for improving disease management.
Materials and Methods: STORICO (NCT03105999), an Italian, multicenter, non-interventional,
observational study conducted in 40 pulmonology centers, aimed to describe the
1-year clinical evolution and health status of clinicallbased phenotypes. Baseline and followup
data of COPD subjects with a chronic bronchitis (CB) or emphysema (EM) phenotype
were collected. The frequency of COPD symptoms during the 24 hours (gathered via the
night-time, morning and day-time symptoms of COPD questionnaire) and the anxiety and
depression levels (via the HADS Scale) were recorded at each visit.
Results: A total of 261 CB and 159 EM patients were analyzed. CB patients with ≥1 night-time
symptom seemed to be more frequent (51.7%, 41.8% and 41.4% at baseline, 6-month and 12-
month follow-up, respectively) than EM (37.7%, 32.1% and 30.2% at study visits) even if no
statistical differences were observed at time points between phenotypes (chi-square test p-values
presence/absence of night-time symptoms in CB vs EM at study visits >0.0007). In the first 6
months, the frequency of patients with ≥1 night-time symptom decreased of 9.9% in CB and of
5.6% in EM. A clinically relevant decline of DLCO % predicted over 1 year in EM was observed,
the mean (SD) being 61.5 (20.8) % at baseline and 59.1 (17.4) % at 12-month follow-up. EM had
higher levels of anxiety and depression than CB (median (25th-75th percentile) HADS total
score in CB: 7.0 (4.0–13.0) and 7.0 (3.0–12.0), in EM: 9.0 (3.0–14.0) and 9.5 (3.0–14.0) both at
baseline and at 6-month follow-up, respectively), considering 1.17 as minimally clinical important
difference (MCID) for the total score.
Conclusion: EM patients, evaluated in a real-world setting, seem to suffer from a worse
clinical condition and health status compared to CB patients, appearing to have “more
treatable” traits.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
COPD; clinical phenotype; clinical evolution; quality of life;
Elenco autori:
F. Blasi, R. Antonelli Incalzi, G.W. Canonica, P. Schino, G. Cuttitta, A. Zullo, A. Ori, N. Scichilone
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