Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma : the role of HCV genotypes and the synergism with hepatitis B virus and alcohol
Articolo
Data di Pubblicazione:
1999
Citazione:
Case-control study on hepatitis C virus (HCV) as a risk factor for hepatocellular carcinoma : the role of HCV genotypes and the synergism with hepatitis B virus and alcohol / A. Tagger, F. Donato, M.L. Ribero, R. Chiesa, G. Portera, U. Gelatti, A. Albertini, M. Fasola, P. Boffetta, G. Nardi. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - 81:5(1999 May 31), pp. 695-699. [10.1002/(SICI)1097-0215(19990531)81:5<695::AID-IJC4>3.0.CO;2-W]
Abstract:
We performed a case-control study to evaluate the risk of hepatocellular
carcinoma (HCC) for hepatitis C virus (HCV)
infection. A total of 305 newly diagnosed HCC cases (80% males) and 610 subjects (81% males) unaffected by clinically evident hepatic disease admitted to the 2 main
hospitals in Brescia, North Italy, were recruited as cases and controls,
respectively. Among the 122 HCC cases positive for HCV RNA, genotype 1b was found in 83 patients (68%), genotype 2 in 36 (29.5%) and genotype 1a in 3 (2.5%). Among the controls, 15 were infected with genotype 1b and 15 with type 2. Analysis of HCV envelope 1 nucleotide sequence among 25
cases and 8 controls infected with genotype 2 showed subtype 2c in 96% of cases and in all controls, and subtype 2a in 1 HCC
case. The odds ratio (OR) for HCV RNA positivity adjusted for hepatitis B virus (HBV) markers and alcohol intake was 26.3 [95% confidence interval (CI): 15.8–44], and it was higher for genotype 1b (OR 5 34.2) than type 2 (OR 5 14.4). The OR for HCV RNA was 35.6 (95% CI: 14.5–87.1) when the HBV
markers were all negative and 132 (15.3–890) when HBsAg positivity was present; the OR was 26.1 (95% CI: 12.6–54.0) among subjects with alcohol intake of 0–40 g/day and increased to 62.6 (23.3–168) and 126 (42.8–373) with an alcohol intake of 41–80 and G80 g/day, respectively. In conclusion, synergism was found between HCV infection and HBV infection and alcohol intake in causing HCC.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hepatitis C virus ; hepatitis B virus ; hepatocellular carcinoma ; HCV genotypes
Elenco autori:
A. Tagger, F. Donato, M.L. Ribero, R. Chiesa, G. Portera, U. Gelatti, A. Albertini, M. Fasola, P. Boffetta, G. Nardi
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