Exercise oscillatory breathing in diastolic heart failure: prevalence and prognostic insights
Articolo
Data di Pubblicazione:
2008
Citazione:
Exercise oscillatory breathing in diastolic heart failure: prevalence and prognostic insights / M. Guazzi, J. Myers, M. A. Peberdy, D. Bensimhon, P. Chase, R. Arena. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 29:22(2008 Nov), pp. 2751-2759.
Abstract:
Aims: Exercise intolerance occurs in both systolic and diastolic heart failure (HF). Exercise oscillatory breathing (EOB) is a powerful predictor of survival in patients with systolic HF. In diastolic HF, EOB prevalence and prognostic impact are unknown. Methods and results: A total of 556 HF patients (405 with systolic HF and 151 with diastolic HF) underwent cardiopulmonary exercise testing (CPET). Diastolic HF was defined as signs and symptoms of HF, a left ventricular ejection fraction ≥50%, and a Doppler early (E) mitral to early mitral annulus ratio (E′) ≥8. CPET responses, EOB prevalence and its ability to predict cardiac-related events were examined. EOB prevalence in systolic and diastolic HF was similar (35 vs. 31%). Compared with the patients without EOB, patients with EOB and either systolic or diastolic HF had a higher New York Heart Association class, lower peak VO2 and higher E/E′ ratio (all P < 0.01). Univariate Cox regression analysis demonstrated that peak VO2, VE/VCO2 slope and EOB all were significant predictors of cardiac events in both systolic and diastolic HF. Multivariable analysis revealed that EOB was retained as a prognostic marker in systolic HF and was the strongest predictor of cardiac events in diastolic HF. Conclusion: EOB occurrence is similar in diastolic and systolic HF and provides relevant clues for the identification of diastolic HF patients at increased risk of adverse events.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Diastolic heart failure; Exercise oscillatory breathing
Elenco autori:
M. Guazzi, J. Myers, M. A. Peberdy, D. Bensimhon, P. Chase, R. Arena
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