A prototype skin substitute, made of recycled marine collagen, improves the skin regeneration of sheep
Articolo
Data di Pubblicazione:
2021
Citazione:
A prototype skin substitute, made of recycled marine collagen, improves the skin regeneration of sheep / L. Melotti, T. Martinello, A. Perazzi, I. Iacopetti, C. Ferrario, M. Sugni, R. Sacchetto, M. Patruno. - In: ANIMALS. - ISSN 2076-2615. - 11:5(2021), pp. 1219.1-1219.20.
Abstract:
Skin wound healing is a complex and dynamic process that aims to restore lesioned tissues. Collagen-based skin substitutes are a promising treatment to promote wound healing by mimicking the native skin structure. Recently, collagen from marine organisms has gained interest as a source for producing biomaterials for skin regenerative strategies. This preliminary study aimed to describe the application of a collagen-based skin-like scaffold (CBSS), manufactured with collagen extracted from sea urchin food waste, to treat experimental skin wounds in a large animal. The wound-healing process was assessed over different time points by the means of clinical, histopathological, and molecular analysis. The CBSS treatment improved wound re-epithelialization along with cell proliferation, gene expression of growth factors (VEGF-A), and development of skin adnexa throughout the healing process. Furthermore, it regulated the gene expression of collagen type I and III, thus enhancing the maturation of the granulation tissue into a mature dermis without any signs of scarring as observed in untreated wounds. The observed results (reduced inflammation, better re-epithelialization, proper development of mature dermis and skin adnexa) suggest that sea urchin-derived CBSS is a promising biomaterial for skin wound healing in a “blue biotechnologies” perspective for animals of Veterinary interest.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
3D scaffolds; Biomaterials; Circular economy; Innovative therapies; Marine collagen; Regenerative medicine; Sea urchin; Skin substitute; Tissue engineering; Wound healing
Elenco autori:
L. Melotti, T. Martinello, A. Perazzi, I. Iacopetti, C. Ferrario, M. Sugni, R. Sacchetto, M. Patruno
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