Hepatitis C virus genotypes : distribution and clinical significance in patients with cirrhosis type C seen at tertiary referral centres in Europe
Articolo
Data di Pubblicazione:
2001
Citazione:
Hepatitis C virus genotypes : distribution and clinical significance in patients with cirrhosis type C seen at tertiary referral centres in Europe / G. Fattovich, M.L. Ribero, M. Pantalena, G. Diodati, P. Almasio, F. Nevens, F. Tremolada, F. Degos, J. Rai, A. Solinas, D. Mura, A. Tocco, I. Zagni, F. Fabris, L. Lomonaco, F. Noventa, G. Realdi, S.W. Schalm, A. Tagger, Eurohep Study Group on Viral Hepatitis. - In: JOURNAL OF VIRAL HEPATITIS. - ISSN 1352-0504. - 8:3(2001 May), pp. 206-216.
Abstract:
The aim of this study was to evaluate the distribution and clinical significance of hepatitis C virus (HCV) genotypes in European patients with compensated cirrhosis due to hepatitis C (Child class A) seen at tertiary referral centres. HCV genotypes were determined by genotype-specific primer PCR in 255 stored serum samples obtained from cirrhotics followed for a median period of 7 years. Inclusion criteria were biopsy-proven cirrhosis, absence of complications of cirrhosis and exclusion of all other potential causes of chronic liver disease. The proportion of patients with types 1b, 2, 3a, 1a, 4 and 5 were 69%, 19%, 6%, 5%, 0.5% and 0.5%, respectively. Kaplan-Meier 5-year risk of hepatocellular carcinoma (HCC) was 6% and 4% for patients infected by type 1b and non-1b, respectively (P=0.8); the corresponding figures for decompensation were 18% and 7% (P=0.0009) and for event-free survival were 79% and 89% (P=0.09), respectively. After adjustment for baseline clinical and serological features, HCV type 1b did not increase the risk for HCC [adjusted relative risk=1.0 (95% confidence interval=0.47-2.34)], whereas it increased the risk for decompensation by a factor of 3 (1.2-7.4) and decreased event-free survival by a factor of 1.7 (0.9-3.10). In conclusion, type 1b and, to a lesser extent, type 2, are the most common HCV genotypes in European patients with cirrhosis. HCV type 1b is not associated with a greater risk for HCC, but increases the risk for decompensation by threefold in patients with cirrhosis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Hepatitis C ; genotypes ; cirrhosis
Elenco autori:
G. Fattovich, M.L. Ribero, M. Pantalena, G. Diodati, P. Almasio, F. Nevens, F. Tremolada, F. Degos, J. Rai, A. Solinas, D. Mura, A. Tocco, I. Zagni, F. Fabris, L. Lomonaco, F. Noventa, G. Realdi, S.W. Schalm, A. Tagger, Eurohep Study Group on Viral Hepatitis
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