Data di Pubblicazione:
2021
Citazione:
Neurotrophic Factor Levels in Preterm Infants : A Systematic Review and Meta-Analysis / F.C. Krey, B.A. Stocchero, K.C. Creutzberg, B.A. Heberle, S.G. Tractenberg, L. Xiang, W. Wei, B. Kluwe-Schiavon, T.W. Viola. - In: FRONTIERS IN NEUROLOGY. - ISSN 1664-2295. - 12(2021 Apr), pp. 643576.1-643576.11.
Abstract:
Objectives: Through a systematic review and meta-analysis of the literature we aimed to compare the levels of BDNF, NGF, NT-3, NT-4, and GDNF between human term and preterm infants, and investigate factors implicated in the variability of effect size estimates. Methods: The analysis was performed in three online databases, MEDLINE Complete, PsycINFO, and CINAHL. A random effects model was used to calculate the standardized mean difference (SMD) of neurotrophic factor levels in preterm infants vs. term within a 95% confidence interval (CI). To explore sources of heterogeneity meta-regression models were implemented. Results: Sixteen studies were included in this meta-analysis. A combined sample of 1,379 preterm and 1,286 term newborns were evaluated. We identified significant lower BDNF (SMD = −0.32; 95% CI: −0.59, −0.06; p = 0.014) and NT-3 (SMD = −0.31; 95% CI: −0.52, −0.09; p = 0.004) levels in preterm compared to term infants. No significant difference was observed in NGF and NT-4 levels between groups. Given that only two effect sizes were generated for GDNF levels, no meta-analytical model was performed. Meta-regression models revealed sample type (placental tissue, cerebrospinal fluid, peripheral blood, and umbilical cord blood) as a significant moderator of heterogeneity for BDNF meta-analysis. No significant associations were found for gestational week, birth weight, and clinical comorbidity of newborns with effect sizes. Conclusions: Our findings indicated that lower BDNF and NT-3 levels may be associated with preterm birth. Future studies with larger samples sizes should investigate neurodevelopmental manifestations resulting from neurotrophic factor dysregulation among preterm infants.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
biomarkers; brain derived neurotrophic factor; infants; neurotrophic factors; neurotrophins; preterm
Elenco autori:
F.C. Krey, B.A. Stocchero, K.C. Creutzberg, B.A. Heberle, S.G. Tractenberg, L. Xiang, W. Wei, B. Kluwe-Schiavon, T.W. Viola
Link alla scheda completa:
Link al Full Text: