Is pre-biopsy serum prostate specific antigen retesting always justified? A study of the influence of individual and analytical factors on decision making for biopsy referral
Articolo
Data di Pubblicazione:
2021
Citazione:
Is pre-biopsy serum prostate specific antigen retesting always justified? A study of the influence of individual and analytical factors on decision making for biopsy referral / S. Ferraro, M. Bussetti, R. Simona Rossi, G. Piero Incarbone, M. Panteghini. - In: CLINICA CHIMICA ACTA. - ISSN 0009-8981. - 516(2021), pp. 77-82.
Abstract:
Background and aims: We investigated factors influencing pre-biopsy prostate-specific antigen (PSA) retesting as recommended by clinical guidelines.
Materials and methods: 333 patients screened for prostate cancer (PCa) repeated PSA (Roche Cobas systems) after a median of 3.9 months, before performing biopsy. Multiple regression models were used to assess effects of patients’ characteristics on PSA results and changes over time.
Results: PCa [n = 132 (40.7%)] and cancer-free [n = 192 (59.3%)] patients had similar rate of PSA positive results at baseline (84.8% vs. 83.9%, P = 0.931). Their rate of reversion to normal PSA after retesting was negligible (0.9% in PCa and 3.7% in PCa-free patients, P = 0.286). 31.1% of PCa and 31.3% of cancer-free patients (P = 0.426) showed a significant PSA increase after retesting. Age was a confounder since not only PSA increased in older PCa patients, but it was also related to PCa histological grade, in turn associated to PSA
increase. In PCa-free patients, glandular inflammation, present in 1/3 of subjects, was also associated to higher PSA concentrations.
Conclusion: When obtained with the same immunoassay under controlled analytical conditions, a PSA positive result is confirmed after retesting in the great majority of screened patients. Neither analytical factors nor intraindividual variability appeared to justify PSA retesting before biopsy referral.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Prostate-specific antigen; Prostatic carcinoma; Clinical practice guidelines; Analytical variation; Biological variation; Biopsy
Elenco autori:
S. Ferraro, M. Bussetti, R. Simona Rossi, G. Piero Incarbone, M. Panteghini
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