Safety and efficacy of L -threonine produced by fermentation with Corynebacterium glutamicum KCCM 80118 for all animal species
Articolo
Data di Pubblicazione:
2019
Citazione:
Safety and efficacy of L -threonine produced by fermentation with Corynebacterium glutamicum KCCM 80118 for all animal species / V. Bampidis, G. Azimonti, M.D.L. Bastos, H. Christensen, B. Dusemund, M. Kouba, M. Kos Durjava, M. Lopez-Alonso, S. Lopez Puente, F. Marcon, B. Mayo, A. Pechova, M. Petkova, F. Ramos, Y. Sanz, R.E. Villa, R. Woutersen, L. Costa, N. Dierick, G. Flachowsky, B. Glandorf, L. Herman, A. Mantovani, M. Saarela, M. Anguita, J. Tarres-Call, R.J. Wallace. - In: EFSA JOURNAL. - ISSN 1831-4732. - 17:3(2019), pp. e05603.1-e05603.14. [10.2903/j.efsa.2019.5603]
Abstract:
Following a request from the European Commission, the Panel on Additives and Products or Substances
used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on L-threonine produced by
fermentation with Corynebacterium glutamicum KCCM 80118 when used as nutritional additive in feed
and water for drinking for all animal species and categories. The product under assessment is L-threonine
produced by fermentation with a genetically modified strain of C. glutamicum (KCCM 80118). The
production strain and its recombinant DNA were not detected in the additive. The product L-threonine,
manufactured by fermentation with C. glutamicum, KCCM80118 does not give rise to any safety concern
with regard to the production strain. L-Threonine produced using C. glutamicum KCCM 80118 is
considered safe for the target species. The FEEDAP Panel has concerns regarding the safety of the
simultaneous oral administration of L-threonine via water for drinking and feed. L-Threonine produced
using C. glutamicum KCCM 80118 is safe for the consumer. The additive is not a skin or eye irritant and
is not a skin sensitiser. Although the workers can be exposed by inhalation, the results of an acute
inhalation study showed that risk of adverse effects by inhalation is low. L-Threonine produced using
C. glutamicum KCCM 80118 is safe for the environment. The product under assessment is considered an
efficacious source of the amino acid L-threonine for all animal species. For L-threonine to be as efficacious
in ruminants as in non-ruminant species, it requires protection against degradation in the rumen.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
amino acid; efficacy; genetically modified microorganism; l-threonine; nutritional additive; safety
Elenco autori:
V. Bampidis, G. Azimonti, M.D.L. Bastos, H. Christensen, B. Dusemund, M. Kouba, M. Kos Durjava, M. Lopez-Alonso, S. Lopez Puente, F. Marcon, B. Mayo, A. Pechova, M. Petkova, F. Ramos, Y. Sanz, R.E. Villa, R. Woutersen, L. Costa, N. Dierick, G. Flachowsky, B. Glandorf, L. Herman, A. Mantovani, M. Saarela, M. Anguita, J. Tarres-Call, R.J. Wallace
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