Circulating preoperative testosterone level predicts unfavourable disease at radical prostatectomy in men with International Society of Urological Pathology Grade Group 1 prostate cancer diagnosed with systematic biopsies
Articolo
Data di Pubblicazione:
2020
Citazione:
Circulating preoperative testosterone level predicts unfavourable disease at radical prostatectomy in men with International Society of Urological Pathology Grade Group 1 prostate cancer diagnosed with systematic biopsies / M. Ferro, G. Lucarelli, O. de Cobelli, M.D. Vartolomei, R. Damiano, F. Cantiello, F. Crocerossa, S. Perdona, P. Del Prete, G. Cordima, G. Musi, F. Del Giudice, G.M. Busetto, B.I. Chung, A. Porreca, P. Ditonno, M. Battaglia, D. Terracciano. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2020). [Epub ahead of print] [10.1007/s00345-020-03368-9]
Abstract:
Purpose: The association between circulating total testosterone (T) levels and clinically significant PCa is still a matter of debate. In this study, we evaluated whether serum testosterone levels may have a role in predicting unfavorable disease (UD) and biochemical recurrence (BCR) in patients with clinically localized (≤ cT2c) ISUP grade group 1 PCa at biopsy. Methods: 408 patients with ISUP grade group 1 prostate cancer, undergone to radical prostatectomy and T measurement were included. The outcome of interest was the presence of unfavourable disease (UD) defined as ISUP grade group ≥ 3 and/or pT ≥ 3a. Results: Statistically significant differences resulted between serum testosterone values and ISUP grade groups (P < 0.0001). Significant correlation was found analyzing testosterone values versus age (P < 0.0001), and versus PSA (P = 0.008). BCR-free survival was significantly decreased in patients with low levels of testosterone (P = 0.005). These findings were confirmed also in the ISUP 1–2 subgroups (P = 0.01). ROC curve analysis showed that T outperformed PSA in predicting UD (AUC 0.718 vs AUC 0.525; P < 0.001) and was and independent risk factor for BCR. Conclusion: Our findings suggested that circulating total T was a significant predictor of UD at RP in patients with preoperative low- to intermediate-risk diseases, confirming the potential role of circulating androgens in preoperative risk assessment of PCa patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ISUP; Prostate cancer; Testosterone; Unfavourable disease; Upgrading; Upstaging
Elenco autori:
M. Ferro, G. Lucarelli, O. de Cobelli, M.D. Vartolomei, R. Damiano, F. Cantiello, F. Crocerossa, S. Perdona, P. Del Prete, G. Cordima, G. Musi, F. Del Giudice, G.M. Busetto, B.I. Chung, A. Porreca, P. Ditonno, M. Battaglia, D. Terracciano
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