Cardiac autonomic function during postural changes and exercise in people with multiple sclerosis : A cross-sectional study
Articolo
Data di Pubblicazione:
2018
Citazione:
Cardiac autonomic function during postural changes and exercise in people with multiple sclerosis : A cross-sectional study / E. Gervasoni, M. Bove, M. Sinatra, C. Grosso, M. Rovaris, D. Cattaneo, G. Merati. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 24(2018 Aug), pp. 85-90.
Abstract:
Background: People with multiple sclerosis (PwMS) often develop an autonomic dysfunction (AD), which onset
should be assessed early at a subclinical level, as it may interfere with pharmacological treatments and exercise.
Objective: To evaluate basal cardiac autonomic tone, its modulations during sit-to-stand, sub-maximal exercise and recovery in PwMS without clinical overt AD and its relationships with fatigue perception.
Methods: Twenty-three PwMS (55 ± 8 yrs [mean ± SD]; EDSS score 5.7 ± 1.3) and 20 age-matched healthy controls (HC; 55 ± 8yrs) were enrolled. ECG was digitally acquired during:1) sitting at rest (low sympathetic
activation); 2) standing (light sympathetic activation); and 3) during light exercise (moderate sympathetic activation) and recovery. Parasympathetic and sympatho-vagal parameters of heart rate (HR) variability in time
and frequency domains were calculated from beat series.
Results: HR was slightly but not significantly higher in PwMS compared to HC in all experimental conditions.
Parasympathetic indexes were significantly lower (p < 0.05) in PwMS compared to HC during baseline sitting
and post-exercise recovery, whereas sympathovagal parameters were similar in both groups. No correlation
between autonomic tone and perceived fatigue was observed.
Conclusion: Parasympathetic tone appears to be impaired in PwMS basal and post-exercise conditions, but not
during postural challenge and exercise. In addition, AD does not affect perceived fatigue.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
multiple sclerosis; autonomic dysfunction; exercise; sit-to-stand; recovery
Elenco autori:
E. Gervasoni, M. Bove, M. Sinatra, C. Grosso, M. Rovaris, D. Cattaneo, G. Merati
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