Combined evaluation of resting IGF-I, N-terminal propeptide of type III procollagen (PIIINP) and C-terminal cross-linked telopeptide of type I collagen (ICTP) levels might be useful for detecting inappropriate GH administration in athletes: a preliminary
Articolo
Data di Pubblicazione:
2004
Citazione:
Combined evaluation of resting IGF-I, N-terminal propeptide of type III procollagen (PIIINP) and C-terminal cross-linked telopeptide of type I collagen (ICTP) levels might be useful for detecting inappropriate GH administration in athletes: a preliminary / A. Sartorio, F. Agosti, N. Marazzi, N.A. Maffiuletti, S.G. Cella, A. Rigamonti, L. Guidetti, L. Di Luigi, E. Muller. - In: CLINICAL ENDOCRINOLOGY. - ISSN 0300-0664. - 61:4(2004), pp. 487-493.
Abstract:
OBJECTIVE
To verify whether combined measurements
of GH-dependent parameters might be useful in detecting
exogenous recombinant GH (rGH) administration
in male athletes from different disciplines.
METHODS
Sixty-six athletes (control group) were
sampled for the evaluation of resting IGF-I, N-terminal
propeptide of type III procollagen (PIIINP) and telopeptide
type I collagen (ICTP). Cut-off values (mean +
2 SD)
for IGF-I, PIIINP and ICTP were calculated and arbitrary
scores (1·5, 2·0) were assigned to abnormal parameters.
By using the sum of individual parameter scores,
positive (≥
3) or negative (< 3) scores were obtained.
In addition, a subgroup of six athletes was treated
for 3 weeks with rGH (0·09 IU/kg body weight, 6 days/
week) and was similarly evaluated at the end of the 1st,
2nd and 3rd week (i.e. 18 samples).
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
A. Sartorio, F. Agosti, N. Marazzi, N.A. Maffiuletti, S.G. Cella, A. Rigamonti, L. Guidetti, L. Di Luigi, E. Muller
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