New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset
Articolo
Data di Pubblicazione:
2009
Citazione:
New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset / A. Cellamare, C. Catacchio, C. Alkan, G. Giannuzzi, F. Antonacci, M. Cardone, G. Della Valle, M. Malig, M. Rocchi, E. Eichler, M. Ventura. - In: MOLECULAR BIOLOGY AND EVOLUTION. - ISSN 0737-4038. - 26:8(2009), pp. 1889-1900. [10.1093/molbev/msp101]
Abstract:
All these data shed light on the evolution of the centromeric sequences in Primates. Our results suggest radical differences in the structure, organization, and evolution of alpha-satellite DNA among different primate species, supporting the notion that 1) all the centromeric sequence in Primates evolved by genomic amplification, unequal crossover, and sequence homogenization using a 171 bp monomer as the basic seeding unit and 2) centromeric function is linked to relatively short repeated elements, more than higher-order structure.
Moreover, our data indicate that complex higher-order repeat structures are a peculiarity of the hominid lineage, showing the more complex organization in humans.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
evolution; primates; centromere
Elenco autori:
A. Cellamare, C. Catacchio, C. Alkan, G. Giannuzzi, F. Antonacci, M. Cardone, G. Della Valle, M. Malig, M. Rocchi, E. Eichler, M. Ventura
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