Data di Pubblicazione:
2006
Citazione:
Shedding light into the role of BDNF in the pharmacotherapy of Parkinson's disease / F. Fumagalli, G. Racagni, M.A. Riva. - In: PHARMACOGENOMICS JOURNAL. - ISSN 1470-269X. - 6:2(2006), pp. 95-104. [10.1038/sj.tpj.6500360]
Abstract:
Parkinson's disease (PD) is a chronic, neurodegenerative disease with a 1% incidence in the population over 55 years of age. Movement impairments represent undoubtedly the hallmark of the disorder; however, extensive evidence implicates cognitive deficits as concomitant peculiar features. Brain-derived neurotrophic factor (BDNF) colocalizes with dopamine neurons in the substantia nigra, where dopaminergic cell bodies are located, and it has recently garnered attention as a molecule crucial for cognition, a function that is also compromised in PD patients. Thus, due to its colocalization with dopaminergic neurons and its role in cognition, BDNF might possess a dual role in PD, both as a neuroprotective molecule, since its inhibition leads to loss of nigral dopaminergic neurons, and as a neuromodulator, as its enhanced expression ameliorates cognitive processes. In this review, we discuss the mechanism of action of established as well as novel drugs for PD with a particular emphasis to those interfering with BDNF biosynthesis
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cognition; Dopaminergic system; Lifestyle; Neurodegenerative disorders; Neurotrophins
Elenco autori:
F. Fumagalli, G. Racagni, M.A. Riva
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