Does microrna perturbation control the mechanisms linking obesity and diabetes? Implications for cardiovascular risk
Articolo
Data di Pubblicazione:
2021
Citazione:
Does microrna perturbation control the mechanisms linking obesity and diabetes? Implications for cardiovascular risk / L.L. Sala, M. Crestani, S. Garavelli, P. de Candia, A.E. Pontiroli. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:1(2021 Jan 01). [10.3390/ijms22010143]
Abstract:
Metabolic disorders such as obesity and type 2 diabetes (T2D) are considered the major risk factors for the development of cardiovascular diseases (CVD). Although the pathological mechanisms underlying the mutual development of obesity and T2D are difficult to define, a better understanding of the molecular aspects is of utmost importance to identify novel therapeutic targets. Recently, a class of non-coding RNAs, called microRNAs (miRNAs), are emerging as key modulators of metabolic abnormalities. There is increasing evidence supporting the role of intra-and extracellular miRNAs as determinants of the crosstalk between adipose tissues, liver, skeletal muscle and other organs, triggering the paracrine communication among different tissues. miRNAs may be considered as risk factors for CVD due to their correlation with cardiovascular events, and in particular, may be related to the most prominent risk factors. In this review, we describe the associations observed between miRNAs expression levels and the most common cardiovascular risk factors. Furthermore, we sought to depict the molecular aspect of the interplay between obesity and diabetes, investigating the role of microRNAs in the interorgan crosstalk. Finally, we discussed the fascinating hypothesis of the loss of protective factors, such as antioxidant defense systems regulated by such miRNAs.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Atherosclerosis; Cardiovascular complications; CVD; Diabetes; Inflammation; Metabolic syndrome; MicroRNA; Obesity; T2D
Elenco autori:
L.L. Sala, M. Crestani, S. Garavelli, P. de Candia, A.E. Pontiroli
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