Data di Pubblicazione:
2020
Citazione:
MINCR : a Long non-coding RNA between cancer and neurodegenerative pathways / C. Pandini, M. Garofalo, F. Rey, J. Garau, G. Berzero, S. Carelli, A. Davin, T. Emanuele Poloni, C. Cereda, S. Gagliardi. ((Intervento presentato al 3. convegno BraYn-Brainstorming Research Assembly for Young Neuroscientist Conference tenutosi a online nel 2020.
Abstract:
The long non-coding RNA (lncRNA) system includes thousands of molecules
involved in fundamental regulatory processes. Many lncRNAs participate to
more than one process and interact with multiple targets, leading to different
outcomes and making extremely challenging to clarify their mechanism of
action. Understanding the multiple functions of non-coding transcripts has
become more and more important in the past years due to the numerous roles
exerted by lncRNAs in physiological or pathological conditions. Therefore,
the aim of this work was to investigate the potential role of the MYC-Induced
Long Non-Coding RNA MINCR depending on its expression level in SH-SY5Y
cells through RNA-seq approach. Since it has been demonstrated that MINCR
is deregulated in different tumours and in Amyotrophic Lateral Sclerosis, we
focused our attention on MINCR potential role in cancer and neurodegeneration.
Our results showed that MINCR overexpression caused great alteration
in the expression level of cancer-related genes leading to disruption in
many fundamental processes, such as cell cycle and growth factor signaling.
Whereas MINCR downregulation highlighted a small number of deregulated
genes involved in different neurodegenerative disorders, mostly concerning
RNA metabolism and inflammation. Taken together, our data showed, firstly,
a new prospect to the mechanisms through which lncRNAs act depending
on their expression level and, secondly, shed light on the interplay between
cancer and neurodegeneration, supporting the idea that these diseases can
share key genes and pathways conversely regulated.
Tipologia IRIS:
14 - Intervento a convegno non pubblicato
Elenco autori:
C. Pandini, M. Garofalo, F. Rey, J. Garau, G. Berzero, S. Carelli, A. Davin, T. Emanuele Poloni, C. Cereda, S. Gagliardi
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