Endocrine-disrupting chemicals' (EDCs) effects on tumour microenvironment and cancer progression : emerging contribution of RACK1
Articolo
Data di Pubblicazione:
2020
Citazione:
Endocrine-disrupting chemicals' (EDCs) effects on tumour microenvironment and cancer progression : emerging contribution of RACK1 / E. Buoso, M. Masi, M. Racchi, E. Corsini. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 21:23(2020 Dec 03), pp. 9229.1-9229.27. [10.3390/ijms21239229]
Abstract:
Endocrine disruptors (EDCs) can display estrogenic and androgenic effects, and their exposure has been linked to increased cancer risk. EDCs have been shown to directly affect cancer cell regulation and progression, but their influence on tumour microenvironment is still not completely elucidated. In this context, the signalling hub protein RACK1 (Receptor for Activated C Kinase 1) could represent a nexus between cancer and the immune system due to its roles in cancer progression and innate immune activation. Since RACK1 is a relevant EDCs target that responds to steroid-active compounds, it could be considered a molecular bridge between the endocrine-regulated tumour microenvironment and the innate immune system. We provide an analysis of immunomodulatory and cancer-promoting effects of different EDCs in shaping tumour microenvironment, with a final focus on the scaffold protein RACK1 as a pivotal molecular player due to its dual role in immune and cancer contexts.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cancer; endocrine disruptors; tumour microenvironment; signal transduction; RACK1; immune system; EMT; ER; cytokine release; inflammation
Elenco autori:
E. Buoso, M. Masi, M. Racchi, E. Corsini
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